Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr9 90345341 . G A CCDS6675.1:NM_001257971.1:c.830gGt>gAt_NP_001244900.1:p.277G>D Homo sapiens cathepsin L (CTSL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1cs8 1 P07711 99.37 0.0 X-RAY
 1999-08-23 GLY A:260 A:164 1.0 0.013 E -88.5 132.9 1.0 0.013 0.0 HOH
 1.872
 O
 H1
6jd8 1 P07711 98.42 0.0 X-RAY
 2020-02-05 ALA A:304 A:260 0.0 0.0 E -92.6 143.3 0.0 0.0 0.0 EOH
PGE
HOH
 8.927
3.252
2.847
 HB2
H
O
 H22
H32
O
6jd0 1 P07711 97.47 0.0 X-RAY
 2020-02-05 ALA A:304 A:260 0.0 0.0 E -100.2 144.5 0.0 0.0 0.0 GOL
POL
HOH
 9.066
3.772
2.789
 HB2
H
O
 O3
O
O
1cjl 1 P07711 98.4 0.0 X-RAY
 1997-08-12 GLY A:256 A:164 1.0 0.013 E -98.2 131.3 1.0 0.013 0.0 HOH
 1.955
 O
 H2
3hwn 1 P07711 99.61 0.0 X-RAY
 2009-09-15 GLY A:202 A:164 4.0 0.053 E -100.4 126.2 4.0 0.053 0.0 BD3
HOH
 3.810
2.821
 N
O
 C14
O
GLY B:202 B:164 5.0 0.067 E -73.1 128.6 NA NA NA
GLY C:202 C:164 6.0 0.08 E -93.4 139.1 NA NA NA
GLY D:202 D:164 6.0 0.08 E -92.0 115.7 NA NA NA
3of8 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 GLY A:165 A:165 4.0 0.053 E -83.5 125.9 4.0 0.053 0.0 I0Y
HOH
 4.232
2.612
 N
O
 C11
O
3of9 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 GLY A:165 A:165 5.0 0.067 E -87.8 129.6 5.0 0.067 0.0 I0X
 3.806
 N
 C3
2xu3 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 GLY A:164 A:164 5.0 0.067 E -97.7 131.2 5.0 0.067 0.0 XU3
BTB
CL
HOH
 2.651
9.022
8.173
2.746
 H
H
H
O
 H4A
H82
CL
O
2xu4 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 GLY A:164 A:164 5.0 0.067 E -97.5 129.4 5.0 0.067 0.0 DJT
GOL
HOH
 2.618
5.280
2.772
 H
H
O
 H13
O3
O
2xu5 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 GLY A:164 A:164 6.0 0.08 E -94.7 131.6 6.0 0.08 0.0 XU5
HOH
 3.612
2.711
 CA
O
 O22
O
2yj2 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLY A:164 A:164 5.0 0.067 E -98.2 130.0 5.0 0.067 0.0 YJ2
HOH
 2.568
2.722
 H
O
 H51
O
2yj8 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLY A:164 A:164 5.0 0.067 E -99.6 127.4 5.0 0.067 0.0 YJ8
HOH
 2.656
2.715
 H
O
 H5
O
2yj9 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLY A:164 A:164 5.0 0.067 E -99.9 128.4 5.0 0.067 0.0 YJ9
HOH
 2.635
2.628
 H
O
 H49
O
2yjb 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLY A:164 A:164 6.0 0.08 E -97.2 130.8 6.0 0.08 0.0 YJ9
HOH
 2.417
2.728
 H
O
 H13
O
2yjc 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLY A:164 A:164 5.0 0.067 E -96.1 129.2 5.0 0.067 0.0 424
HOH
 3.135
2.727
 HA2
O
 O18
O
3bc3 1 P07711 100.0 3e-166 X-RAY
 2008-03-18 GLY A:164 A:164 7.0 0.093 E -82.3 124.3 7.0 0.093 0.0 OPT
HOH
 3.550
2.600
 N
O
 C44
O
GLY B:164 B:164 5.0 0.067 E -86.3 130.2 NA NA NA
3h89 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 GLY A:164 A:164 6.0 0.08 E -88.7 129.2 6.0 0.08 0.0 NSX
HOH
 3.773
4.580
 N
O
 C44
O
GLY B:164 B:164 7.0 0.093 E -88.3 128.9 NA NA NA
GLY C:164 C:164 6.0 0.08 E -89.7 126.8 NA NA NA
GLY D:164 D:164 6.0 0.08 E -86.5 133.2 NA NA NA
GLY E:164 E:164 7.0 0.093 E -91.0 127.4 NA NA NA
GLY F:164 F:164 8.0 0.107 E -91.7 122.3 NA NA NA
3h8b 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 GLY A:164 A:164 7.0 0.093 E -82.4 131.7 7.0 0.093 0.0 NSY
HOH
 3.672
2.702
 N
O
 C44
O
GLY B:164 B:164 5.0 0.067 E -81.7 134.7 NA NA NA
GLY C:164 C:164 6.0 0.08 E -81.2 133.2 NA NA NA
GLY D:164 D:164 5.0 0.067 E -82.8 133.9 NA NA NA
GLY E:164 E:164 7.0 0.093 E -84.5 132.2 NA NA NA
GLY F:164 F:164 7.0 0.093 E -87.0 132.8 NA NA NA
3h8c 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 GLY A:164 A:164 6.0 0.08 E -81.7 142.6 6.0 0.08 0.0 NSZ
HOH
 3.903
2.904
 N
O
 C44
O
GLY B:164 B:164 6.0 0.08 E -83.7 133.9 NA NA NA
4axl 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 GLY A:164 A:164 3.0 0.04 E -74.9 127.6 3.0 0.04 0.0 ZN
HOH
 4.880
2.654
 N
O
 ZN
O
4axm 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 GLY A:164 A:164 5.0 0.067 E -93.6 140.9 5.0 0.067 0.0 V65
HOH
 3.146
4.378
 N
O
 C18
O
GLY B:164 B:164 4.0 0.053 E -100.2 125.2 NA NA NA
GLY C:164 F:164 4.0 0.053 E -109.5 130.2 NA NA NA
GLY D:164 I:164 5.0 0.067 E -90.0 144.1 NA NA NA
GLY E:164 L:164 5.0 0.067 E -102.3 135.3 NA NA NA
GLY F:164 O:164 7.0 0.093 E -78.2 141.1 NA NA NA
5f02 1 P07711 100.0 3e-166 X-RAY
 2016-02-24 GLY A:164 A:164 5.0 0.067 E -97.6 126.6 5.0 0.067 0.0 GOL
5T9
HOH
 9.978
2.676
2.629
 O
H
O
 O2
H42
O
5mae 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 GLY A:164 A:164 4.0 0.053 E -107.7 133.6 4.0 0.053 0.0 7KN
EDO
HOH
 4.014
7.339
2.748
 N
N
O
 C20
C1
O
5maj 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 GLY A:164 A:164 3.0 0.04 E -106.2 133.2 3.0 0.04 0.0 7KH
HOH
 3.995
2.751
 N
O
 C13
O
5mqy 1 P07711 100.0 3e-166 X-RAY
 2017-03-22 GLY A:164 A:164 4.0 0.053 E -96.6 134.7 4.0 0.053 0.0 GH4
EDO
HOH
 3.696
7.363
2.671
 N
N
O
 C18
C1
O
6ezp 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 GLY A:164 A:164 0.0 0.0 E -84.0 132.3 0.0 0.0 0.0 C3E
HOH
 3.837
2.783
 N
O
 CB
O
6ezx 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 GLY A:164 A:164 5.0 0.067 E -103.0 129.4 5.0 0.067 0.0 C7Q
HOH
 3.847
2.658
 N
O
 C9
O
GLY B:164 B:164 6.0 0.08 E -86.3 133.5 6.0 0.08 0.0 C7Q
HOH
 3.794
3.096
 N
O
 C9
O
6f06 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 GLY A:164 A:164 5.0 0.067 E -83.7 131.9 5.0 0.067 0.0 C7T
ZN
CL
HOH
 4.129
4.310
6.441
4.343
 N
N
N
O
 C12
ZN
CL
O
GLY B:164 B:164 5.0 0.067 E -86.4 132.9 NA NA NA
2nqd 2 P07711 99.55 1e-165 X-RAY
 2007-07-24 GLY B:165 B:164 9.0 0.12 E -94.7 126.1 1.0 0.013 0.107 A:Q966X9:0.107
 HOH
 2.752
 O
 O
2xu1 1 P07711 99.55 2e-165 X-RAY
 2011-01-12 GLY A:164 A:164 4.0 0.053 E -105.3 127.2 4.0 0.053 0.0 424
HOH
 3.673
2.750
 CA
O
 O18
O
GLY B:164 B:164 5.0 0.067 E -97.9 128.2 NA NA NA
GLY C:164 C:164 4.0 0.053 E -105.4 128.8 NA NA NA
GLY D:164 D:164 4.0 0.053 E -109.6 129.0 NA NA NA
3hha 1 P07711 99.55 2e-165 X-RAY
 2009-06-23 GLY A:164 A:164 4.0 0.053 E -89.1 132.6 4.0 0.053 0.0 NOW
PG4
ACT
HOH
 3.922
8.074
7.757
2.730
 N
N
N
O
 C8
O1
CH3
O
GLY B:164 B:164 6.0 0.08 E -88.4 131.6 NA NA NA
GLY C:164 C:164 4.0 0.053 E -89.2 131.5 NA NA NA
GLY D:164 D:164 5.0 0.067 E -94.0 133.0 NA NA NA
3iv2 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 GLY A:164 A:164 4.0 0.053 E -71.7 130.8 4.0 0.053 0.0 SO4
HOH
 4.438
2.751
 N
O
 O2
O
GLY B:164 B:164 5.0 0.067 E -79.0 132.2 5.0 0.067 0.0 GOL
SO4
HOH
 9.604
4.256
2.531
 O
N
O
 C3
O3
O
3k24 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 GLY A:164 A:164 9.0 0.12 E -88.1 133.9 1.0 0.013 0.107 D:None:0.107
 HOH
 2.755
 O
 O
GLY B:164 B:164 8.0 0.107 E -94.3 131.8 NA NA NA
3kse 1 P07711 99.09 8e-165 X-RAY
 2010-12-01 GLY A:164 A:164 4.0 0.053 E -113.7 131.8 0.0 0.0 0.053 D:P01040:0.053
 HOH
 2.716
 O
 O
GLY B:164 B:164 4.0 0.053 E -112.8 131.4 NA NA NA
GLY C:164 C:164 4.0 0.053 E -108.8 136.0 NA NA NA
2vhs 1 P07711 91.82 1e-145 X-RAY
 2008-03-11 ALA A:164 A:164 6.0 0.052 E -88.5 147.0 6.0 0.052 0.0 SO4
HOH
 4.419
2.699
 N
O
 O3
O
ALA B:164 B:164 7.0 0.061 E -89.3 146.6 7.0 0.061 0.0 SO4
HOH
 4.352
2.733
 N
O
 O4
O
ALA C:164 C:164 6.0 0.052 E -84.9 143.4 6.0 0.052 0.0 SO4
HOH
 4.271
2.681
 N
O
 O4
O
ALA D:164 D:164 7.0 0.061 E -85.8 146.8 7.0 0.061 0.0 SO4
HOH
 4.426
2.750
 N
O
 O3
O
1icf 1 P07711 100.0 1e-129 X-RAY
 2000-01-12 GLY A:164 A:164 9.0 0.12 E -86.4 134.6 1.0 0.013 0.107 B:P07711:0.04
E:P04233:0.08
 HOH
 2.667
 O
 O
GLY C:164 C:164 8.0 0.107 E -84.5 131.2 NA NA NA
1mhw 1 P07711 100.0 1e-129 X-RAY
 2002-12-11 GLY A:164 A:164 9.0 0.12 E -85.5 127.0 0.0 0.0 0.12 B:P07711:0.04
G:None:0.067
 HOH
 2.748
 O
 O
GLY C:164 B:164 10.0 0.133 E -89.1 126.6 NA NA NA
5i4h 2 P07711 99.11 9e-78 X-RAY
 2016-04-13 GLY B:56 B:164 52.0 0.693 E -87.5 138.3 4.0 0.053 0.64 A:P07711:0.64
 HOH
 2.254
 O
 H2

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p07711-f1 1 P07711 100.0 0.0 GLY A:277 A:277 0.0 0.0 E -90.9 127.2