Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr9 90345935 . A C CCDS6675.1:NM_001257971.1:c.915gaA>gaC_NP_001244900.1:p.305E>D Homo sapiens cathepsin L (CTSL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1cs8 1 P07711 99.37 0.0 X-RAY
 1999-08-23 GLU A:288 A:192 108.0 0.568 T -72.3 -12.4 108.0 0.568 0.0 HOH
 2.017
 O
 H2
6jd8 1 P07711 98.42 0.0 X-RAY
 2020-02-05 GLU A:332 A:288 91.0 0.479 T -67.6 -27.5 91.0 0.479 0.0 HOH
 2.181
 H
 O
6jd0 1 P07711 97.47 0.0 X-RAY
 2020-02-05 GLU A:332 A:288 100.0 0.526 T -70.0 -28.5 100.0 0.526 0.0 NA
PO4
PO4
POL
POL
PGE
HOH
 6.006
8.608
2.339
7.118
7.967
8.271
2.726
 H
O
H
OE2
H
OE1
OE1
 NA
O1
O2
H33
HO
HO1
O
1cjl 1 P07711 98.4 0.0 X-RAY
 1997-08-12 GLU A:284 A:192 167.0 0.879 T -80.7 -4.8 167.0 0.879 0.0 HOH
 2.289
 O
 H2
3hwn 1 P07711 99.61 0.0 X-RAY
 2009-09-15 GLU A:230 A:192 189.0 0.995 T -65.6 -20.6 189.0 0.995 0.0 HOH
 6.382
 N
 O
GLU B:230 B:192 199.0 1.0 T -74.4 -17.8 NA NA NA
GLU C:230 C:192 199.0 1.0 T -73.6 -37.7 NA NA NA
GLU D:230 D:192 196.0 1.0 T -118.6 -15.3 NA NA NA
3of8 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 GLU A:193 A:193 146.0 0.768 T -85.7 -0.4 146.0 0.768 0.0 HOH
 5.915
 N
 O
3of9 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 GLU A:193 A:193 163.0 0.858 T -81.4 -6.3 163.0 0.858 0.0
2xu3 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 GLU A:192 A:192 154.0 0.811 T -72.3 -17.8 154.0 0.811 0.0 BTB
HOH
 5.876
1.136
 HB2
OE1
 H31
O
2xu4 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 GLU A:192 A:192 197.0 1.0 T -85.0 -8.8 197.0 1.0 0.0 GOL
HOH
 9.401
2.299
 HB2
H
 O3
O
2xu5 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 GLU A:192 A:192 171.0 0.9 T -89.3 -14.1 171.0 0.9 0.0 FLC
HOH
 7.584
2.768
 C
O
 OA1
O
2yj2 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLU A:192 A:192 149.0 0.784 T -65.8 -33.4 149.0 0.784 0.0 GOL
HOH
 6.002
1.601
 OE1
OE1
 H31
O
2yj8 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLU A:192 A:192 147.0 0.774 T -69.5 -28.9 147.0 0.774 0.0 GOL
HOH
 5.519
2.783
 OE1
OE2
 H31
O
2yj9 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLU A:192 A:192 157.0 0.826 T -82.1 -8.9 157.0 0.826 0.0 HOH
 3.267
 HA
 O
2yjb 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLU A:192 A:192 154.0 0.811 T -70.4 -27.0 154.0 0.811 0.0 GOL
HOH
 5.043
2.506
 OE2
H
 H32
O
2yjc 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 GLU A:192 A:192 191.0 1.0 T -87.3 -3.6 191.0 1.0 0.0 HOH
 2.323
 H
 O
3bc3 1 P07711 100.0 3e-166 X-RAY
 2008-03-18 GLU A:192 A:192 166.0 0.874 S -86.1 -19.2 166.0 0.874 0.0 OPT
HOH
 7.045
2.890
 C
O
 C13
O
GLU B:192 B:192 167.0 0.879 T -80.0 -20.6 NA NA NA
3h89 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 GLU A:192 A:192 175.0 0.921 T -95.7 5.2 175.0 0.921 0.0 HOH
 6.222
 N
 O
GLU B:192 B:192 176.0 0.926 T -96.2 5.9 NA NA NA
GLU C:192 C:192 176.0 0.926 T -103.6 6.7 NA NA NA
GLU D:192 D:192 187.0 0.984 T -80.3 1.3 NA NA NA
GLU E:192 E:192 157.0 0.826 T -88.9 -11.8 NA NA NA
GLU F:192 F:192 167.0 0.879 T -91.3 0.3 NA NA NA
3h8b 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 GLU A:192 A:192 170.0 0.895 T -91.7 -3.4 170.0 0.895 0.0 HOH
 2.798
 N
 O
GLU B:192 B:192 169.0 0.889 T -92.6 -3.0 NA NA NA
GLU C:192 C:192 186.0 0.979 T -80.9 -2.1 NA NA NA
GLU D:192 D:192 177.0 0.932 T -80.8 -4.0 NA NA NA
GLU E:192 E:192 168.0 0.884 T -89.1 -10.9 NA NA NA
GLU F:192 F:192 167.0 0.879 T -88.9 -12.0 NA NA NA
3h8c 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 GLU A:192 A:192 175.0 0.921 T -73.6 -19.3 175.0 0.921 0.0 NSZ
HOH
 7.647
3.206
 CB
OE1
 C10
O
GLU B:192 B:192 173.0 0.911 S -70.0 -31.8 NA NA NA
4axl 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 GLU A:192 A:192 164.0 0.863 T -78.6 -16.6 164.0 0.863 0.0 GOL
GOL
HOH
 2.742
8.051
3.021
 OE1
O
O
 O3
C1
O
4axm 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 GLU A:192 A:192 134.0 0.705 T -54.9 -45.8 134.0 0.705 0.0 GOL
HOH
 5.945
3.027
 OE1
OE2
 O3
O
GLU B:192 B:192 136.0 0.716 T -55.3 -41.1 NA NA NA
GLU C:192 F:192 132.0 0.695 S -67.6 -39.2 NA NA NA
GLU D:192 I:192 144.0 0.758 T -60.6 -43.7 NA NA NA
GLU E:192 L:192 149.0 0.784 T -65.4 -20.2 NA NA NA
GLU F:192 O:192 140.0 0.737 T -66.9 -45.6 NA NA NA
5f02 1 P07711 100.0 3e-166 X-RAY
 2016-02-24 GLU A:192 A:192 197.0 1.0 T -86.6 -8.9 197.0 1.0 0.0 GOL
HOH
 7.742
3.149
 H
HA
 O1
O
5mae 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 GLU A:192 A:192 193.0 1.0 T -81.2 -10.1 193.0 1.0 0.0 HOH
 3.076
 N
 O
5maj 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 GLU A:192 A:192 194.0 1.0 T -84.8 -7.7 194.0 1.0 0.0 HOH
 2.735
 OE2
 O
5mqy 1 P07711 100.0 3e-166 X-RAY
 2017-03-22 GLU A:192 A:192 200.0 1.0 T -79.8 -4.5 200.0 1.0 0.0 HOH
 2.591
 OE1
 O
6ezp 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 GLU A:192 A:192 191.0 1.0 S -79.2 -28.5 191.0 1.0 0.0 GOL
HOH
 8.591
3.038
 CB
O
 C1
O
6ezx 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 GLU A:192 A:192 191.0 1.0 T -75.5 -14.9 191.0 1.0 0.0 HOH
 6.560
 N
 O
GLU B:192 B:192 179.0 0.942 T -76.8 -19.0 179.0 0.942 0.0 HOH
 6.169
 N
 O
6f06 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 GLU A:192 A:192 146.0 0.768 T -74.3 -17.4 146.0 0.768 0.0 HOH
 4.512
 O
 O
GLU B:192 B:192 155.0 0.816 S -79.4 -37.8 NA NA NA
2nqd 2 P07711 99.55 1e-165 X-RAY
 2007-07-24 GLU B:193 B:192 174.0 0.916 T -75.6 -9.1 146.0 0.768 0.148 A:Q966X9:0.147
 HOH
 2.677
 O
 O
2xu1 1 P07711 99.55 2e-165 X-RAY
 2011-01-12 GLU A:192 A:192 154.0 0.811 T -76.4 -24.4 154.0 0.811 0.0 HOH
 2.895
 OE2
 O
GLU B:192 B:192 154.0 0.811 T -77.1 -19.6 NA NA NA
GLU C:192 C:192 194.0 1.0 T -70.0 -28.5 NA NA NA
GLU D:192 D:192 177.0 0.932 S -69.3 -41.9 NA NA NA
3hha 1 P07711 99.55 2e-165 X-RAY
 2009-06-23 GLU A:192 A:192 156.0 0.821 T -78.8 -17.7 156.0 0.821 0.0 HOH
 2.525
 OE1
 O
GLU B:192 B:192 192.0 1.0 T -79.8 -23.0 NA NA NA
GLU C:192 C:192 166.0 0.874 S -74.4 -35.0 NA NA NA
GLU D:192 D:192 181.0 0.953 T -90.7 -19.4 NA NA NA
3iv2 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 GLU A:192 A:192 175.0 0.921 T -87.2 -11.5 85.0 0.447 0.474 B:P07711:0.474
 SO4
HOH
 2.901
4.930
 CG
O
 O2
O
GLU B:192 B:192 171.0 0.9 T -87.4 -15.4 91.0 0.479 0.421 A:P07711:0.421
 GOL
HOH
 2.495
5.093
 CG
O
 O3
O
3k24 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 GLU A:192 A:192 151.0 0.795 T -75.1 -22.8 151.0 0.795 0.0 HOH
 2.865
 OE2
 O
GLU B:192 B:192 162.0 0.853 T -72.8 -32.3 NA NA NA
3kse 1 P07711 99.09 8e-165 X-RAY
 2010-12-01 GLU A:192 A:192 174.0 0.916 S -81.8 -30.7 113.0 0.595 0.321 D:P01040:0.321
 HOH
 2.951
 O
 O
GLU B:192 B:192 178.0 0.937 S -76.9 -36.6 NA NA NA
GLU C:192 C:192 175.0 0.921 S -84.9 -27.5 NA NA NA
2vhs 1 P07711 91.82 1e-145 X-RAY
 2008-03-11 GLU A:189 A:192 183.0 0.963 T -79.1 -22.9 183.0 0.963 0.0 HOH
 2.918
 O
 O
GLU B:189 B:192 173.0 0.911 T -80.2 -25.8 173.0 0.911 0.0 HOH
 2.758
 OE2
 O
GLU C:189 C:192 168.0 0.884 S -78.2 -33.5 168.0 0.884 0.0 HOH
 2.619
 OE2
 O
GLU D:189 D:192 180.0 0.947 T -79.0 -29.7 180.0 0.947 0.0 HOH
 3.117
 O
 O
5i4h 2 P07711 99.11 9e-78 X-RAY
 2016-04-13 GLU B:84 B:192 173.0 0.911 T -80.2 -12.2 173.0 0.911 0.0 SO4
HOH
 2.318
2.154
 H
H
 O4
O
1icf 2 P07711 100.0 1e-23 X-RAY
 2000-01-12 GLU B:14 B:192 193.0 1.0 T -78.1 -28.3 180.0 0.947 0.053 A:P07711:0.042
E:P04233:0.026
 HOH
 3.269
 O
 O
GLU D:14 D:192 191.0 1.0 T -78.9 -29.7 NA NA NA
1mhw 2 P07711 100.0 1e-23 X-RAY
 2002-12-11 GLU B:14 C:192 169.0 0.889 S -83.4 -33.5 169.0 0.889 0.0 HOH
 2.776
 OE2
 O
GLU D:14 D:192 184.0 0.968 T -65.7 -31.0 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p07711-f1 1 P07711 100.0 0.0 GLU A:305 A:305 139.0 0.732 T -71.7 -23.1