Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr9 90343522 . C A CCDS6675.1:NM_001257971.1:c.419gCt>gAt_NP_001244900.1:p.140A>D Homo sapiens cathepsin L (CTSL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1cs8 1 P07711 99.37 0.0 X-RAY
 1999-08-23 ALA A:123 A:27 0.0 0.0 H -70.1 -42.2 0.0 0.0 0.0 HOH
 4.918
 O
 H1
6jd8 1 P07711 98.42 0.0 X-RAY
 2020-02-05 ALA A:167 A:123 0.0 0.0 H -73.3 -37.3 0.0 0.0 0.0 EOH
EOH
EOH
EOH
PGE
HOH
 9.613
9.310
9.615
6.598
5.077
5.020
 H
HB2
O
HB3
H
O
 H22
HO
HO
HO
H3
O
6jd0 1 P07711 97.47 0.0 X-RAY
 2020-02-05 ALA A:167 A:123 0.0 0.0 H -74.2 -38.3 0.0 0.0 0.0 POL
POL
EOH
HOH
 8.982
4.588
8.159
5.773
 HB3
H
HB2
O
 H33
H31
H11
O
1cjl 1 P07711 98.4 0.0 X-RAY
 1997-08-12 ALA A:119 A:27 0.0 0.0 H -70.8 -40.4 0.0 0.0 0.0 HOH
 4.873
 O
 H2
3hwn 1 P07711 99.61 0.0 X-RAY
 2009-09-15 ALA A:65 A:27 0.0 0.0 H -71.1 -40.8 0.0 0.0 0.0 BD3
HOH
 7.064
5.539
 N
C
 C24
O
ALA B:65 B:27 0.0 0.0 H -74.4 -38.5 NA NA NA
ALA C:65 C:27 0.0 0.0 H -87.6 -22.8 NA NA NA
ALA D:65 D:27 0.0 0.0 H -76.0 -16.8 NA NA NA
3of8 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 ALA A:28 A:28 0.0 0.0 H -69.4 -39.4 0.0 0.0 0.0 I0Y
HOH
 6.739
5.674
 N
O
 O3
O
3of9 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 ALA A:28 A:28 0.0 0.0 H -72.6 -37.9 0.0 0.0 0.0 I0X
 6.577
 N
 O1
2xu3 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 ALA A:27 A:27 0.0 0.0 H -70.0 -42.0 0.0 0.0 0.0 XU3
CL
HOH
 6.065
9.437
5.767
 H
H
O
 H4
CL
O
2xu4 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 ALA A:27 A:27 0.0 0.0 H -71.6 -38.0 0.0 0.0 0.0 DJT
GOL
HOH
 6.042
9.529
5.759
 H
H
O
 H13A
O3
O
2xu5 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 ALA A:27 A:27 0.0 0.0 H -72.5 -36.9 0.0 0.0 0.0 XU5
HOH
 6.679
5.796
 N
O
 O6
O
2yj2 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ALA A:27 A:27 0.0 0.0 H -71.5 -38.7 0.0 0.0 0.0 YJ2
HOH
 6.022
5.800
 H
O
 H52
O
2yj8 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ALA A:27 A:27 0.0 0.0 H -67.5 -39.9 0.0 0.0 0.0 YJ8
HOH
 6.002
5.728
 H
O
 H5A
O
2yj9 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ALA A:27 A:27 0.0 0.0 H -73.4 -38.3 0.0 0.0 0.0 YJ9
HOH
 6.031
5.832
 H
O
 H13
O
2yjb 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ALA A:27 A:27 0.0 0.0 H -77.6 -37.7 0.0 0.0 0.0 YJ9
HOH
 6.102
5.698
 H
O
 H49
O
2yjc 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 ALA A:27 A:27 0.0 0.0 H -71.4 -39.9 0.0 0.0 0.0 424
HOH
 6.354
5.731
 H
O
 C15
O
3bc3 1 P07711 100.0 3e-166 X-RAY
 2008-03-18 ALA A:27 A:27 0.0 0.0 H -70.5 -43.9 0.0 0.0 0.0 OPT
HOH
 7.593
5.887
 N
O
 C46
O
ALA B:27 B:27 0.0 0.0 H -71.5 -41.4 NA NA NA
3h89 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 ALA A:27 A:27 0.0 0.0 H -75.0 -39.3 0.0 0.0 0.0 NSX
HOH
 7.362
2.737
 N
CB
 O39
O
ALA B:27 B:27 0.0 0.0 H -74.3 -37.9 NA NA NA
ALA C:27 C:27 0.0 0.0 H -73.0 -32.6 NA NA NA
ALA D:27 D:27 0.0 0.0 H -79.2 -37.1 NA NA NA
ALA E:27 E:27 0.0 0.0 H -72.4 -39.4 NA NA NA
ALA F:27 F:27 0.0 0.0 H -71.6 -43.8 NA NA NA
3h8b 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 ALA A:27 A:27 0.0 0.0 H -71.9 -39.2 0.0 0.0 0.0 NSY
HOH
 7.535
5.784
 N
O
 O39
O
ALA B:27 B:27 0.0 0.0 H -71.9 -38.7 NA NA NA
ALA C:27 C:27 0.0 0.0 H -71.3 -39.3 NA NA NA
ALA D:27 D:27 0.0 0.0 H -70.9 -38.7 NA NA NA
ALA E:27 E:27 0.0 0.0 H -73.9 -37.5 NA NA NA
ALA F:27 F:27 0.0 0.0 H -74.9 -37.1 NA NA NA
3h8c 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 ALA A:27 A:27 0.0 0.0 H -67.4 -40.7 0.0 0.0 0.0 NSZ
HOH
 7.583
5.972
 N
O
 O39
O
ALA B:27 B:27 0.0 0.0 H -70.8 -39.7 NA NA NA
4axl 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 ALA A:27 A:27 0.0 0.0 H -68.5 -40.5 0.0 0.0 0.0 ZN
HOH
 8.787
5.675
 N
O
 ZN
O
4axm 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 ALA A:27 A:27 0.0 0.0 H -76.9 -50.9 0.0 0.0 0.0 V65
HOH
 6.921
7.198
 N
C
 C1
O
ALA B:27 B:27 0.0 0.0 H -63.7 -42.3 NA NA NA
ALA C:27 F:27 0.0 0.0 H -70.4 -39.6 NA NA NA
ALA D:27 I:27 0.0 0.0 H -72.1 -28.0 NA NA NA
ALA E:27 L:27 0.0 0.0 H -68.7 -48.6 NA NA NA
ALA F:27 O:27 0.0 0.0 H -80.5 -39.8 NA NA NA
5f02 1 P07711 100.0 3e-166 X-RAY
 2016-02-24 ALA A:27 A:27 0.0 0.0 H -69.0 -38.7 0.0 0.0 0.0 5T9
HOH
 5.984
5.691
 H
O
 H43
O
5mae 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 ALA A:27 A:27 0.0 0.0 H -72.8 -40.6 0.0 0.0 0.0 7KN
HOH
 6.843
5.709
 N
O
 C8
O
5maj 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 ALA A:27 A:27 0.0 0.0 H -71.7 -40.4 0.0 0.0 0.0 7KH
HOH
 6.919
5.714
 N
O
 C8
O
5mqy 1 P07711 100.0 3e-166 X-RAY
 2017-03-22 ALA A:27 A:27 0.0 0.0 H -70.1 -40.6 0.0 0.0 0.0 GH4
EDO
HOH
 6.827
9.225
5.741
 N
C
O
 C24
C2
O
6ezp 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 ALA A:27 A:27 0.0 0.0 H -72.4 -39.7 0.0 0.0 0.0 C3E
HOH
 6.821
5.632
 N
O
 O
O
6ezx 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 ALA A:27 A:27 0.0 0.0 H -74.3 -28.5 0.0 0.0 0.0 C7Q
HOH
 6.642
5.751
 N
O
 O20
O
ALA B:27 B:27 0.0 0.0 H -71.2 -48.8 0.0 0.0 0.0 C7Q
HOH
 6.969
5.779
 N
O
 O20
O
6f06 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 ALA A:27 A:27 0.0 0.0 H -70.7 -43.1 0.0 0.0 0.0 C7T
ZN
ZN
CL
HOH
 6.925
8.109
7.552
8.888
5.418
 N
N
O
N
O
 O15
ZN
ZN
CL
O
ALA B:27 B:27 0.0 0.0 H -69.8 -43.7 NA NA NA
2nqd 2 P07711 99.55 1e-165 X-RAY
 2007-07-24 ALA B:28 B:27 0.0 0.0 H -74.8 -37.6 0.0 0.0 0.0 HOH
 5.528
 N
 O
2xu1 1 P07711 99.55 2e-165 X-RAY
 2011-01-12 ALA A:27 A:27 0.0 0.0 H -75.1 -34.8 0.0 0.0 0.0 424
HOH
 6.883
5.722
 N
O
 C15
O
ALA B:27 B:27 0.0 0.0 H -74.1 -37.2 NA NA NA
ALA C:27 C:27 0.0 0.0 H -72.6 -37.5 NA NA NA
ALA D:27 D:27 0.0 0.0 H -71.9 -36.4 NA NA NA
3hha 1 P07711 99.55 2e-165 X-RAY
 2009-06-23 ALA A:27 A:27 0.0 0.0 H -70.6 -38.6 0.0 0.0 0.0 NOW
HOH
 6.801
5.771
 N
O
 O11
O
ALA B:27 B:27 0.0 0.0 H -73.1 -38.5 NA NA NA
ALA C:27 C:27 0.0 0.0 H -73.5 -37.3 NA NA NA
ALA D:27 D:27 0.0 0.0 H -73.8 -37.7 NA NA NA
3iv2 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 ALA A:27 A:27 0.0 0.0 H -74.1 -37.6 0.0 0.0 0.0 SO4
HOH
 6.689
6.322
 N
O
 O4
O
ALA B:27 B:27 0.0 0.0 H -77.0 -39.1 0.0 0.0 0.0 SO4
HOH
 6.661
6.347
 N
O
 O4
O
3k24 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 ALA A:27 A:27 0.0 0.0 H -86.8 -30.9 0.0 0.0 0.0 HOH
 6.912
 C
 O
ALA B:27 B:27 0.0 0.0 H -78.5 -39.0 NA NA NA
3kse 1 P07711 99.09 8e-165 X-RAY
 2010-12-01 ALA A:27 A:27 0.0 0.0 H -74.3 -37.4 0.0 0.0 0.0 HOH
 5.686
 O
 O
ALA B:27 B:27 0.0 0.0 H -74.1 -36.9 NA NA NA
ALA C:27 C:27 0.0 0.0 H -76.6 -35.2 NA NA NA
2vhs 1 P07711 91.82 1e-145 X-RAY
 2008-03-11 ALA A:27 A:27 0.0 0.0 H -71.3 -41.5 0.0 0.0 0.0 SO4
HOH
 6.853
5.413
 N
N
 O4
O
ALA B:27 B:27 0.0 0.0 H -70.2 -39.0 0.0 0.0 0.0 SO4
HOH
 6.891
5.520
 N
N
 O1
O
ALA C:27 C:27 0.0 0.0 H -71.7 -40.3 0.0 0.0 0.0 SO4
HOH
 6.838
5.519
 N
N
 O1
O
ALA D:27 D:27 0.0 0.0 H -71.8 -40.9 0.0 0.0 0.0 SO4
HOH
 6.835
5.430
 N
N
 O4
O
1icf 1 P07711 100.0 1e-129 X-RAY
 2000-01-12 ALA A:27 A:27 0.0 0.0 H -75.2 -38.1 0.0 0.0 0.0 HOH
 5.810
 O
 O
ALA C:27 C:27 0.0 0.0 H -73.6 -36.0 NA NA NA
1mhw 1 P07711 100.0 1e-129 X-RAY
 2002-12-11 ALA A:27 A:27 0.0 0.0 H -70.0 -38.7 0.0 0.0 0.0 HOH
 5.733
 O
 O
ALA C:27 B:27 0.0 0.0 H -73.1 -41.4 NA NA NA
5i4h 1 P07711 99.06 5e-73 X-RAY
 2016-04-13 ALA A:28 A:27 0.0 0.0 H -73.7 -38.9 0.0 0.0 0.0 HOH
 5.523
 O
 H1

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p07711-f1 1 P07711 100.0 0.0 ALA A:140 A:140 0.0 0.0 H -68.7 -45.2