Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr9 90345924 . T A CCDS6675.1:NM_001257971.1:c.904Tgg>Agg_NP_001244900.1:p.302W>R Homo sapiens cathepsin L (CTSL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1cs8 1 P07711 99.37 0.0 X-RAY
 1999-08-23 TRP A:285 A:189 3.0 0.012 B -112.9 27.3 3.0 0.012 0.0 HOH
 1.861
 O
 H2
6jd8 1 P07711 98.42 0.0 X-RAY
 2020-02-05 TRP A:329 A:285 9.0 0.035 B -111.9 20.9 9.0 0.035 0.0 EOH
EOH
EOH
EDO
PGE
HOH
 8.227
9.506
8.518
9.202
3.227
2.077
 HA
HH2
N
HA
HE1
H
 H11
H12
H11
H12
H12
O
6jd0 1 P07711 97.47 0.0 X-RAY
 2020-02-05 TRP A:329 A:285 8.0 0.031 B -115.8 27.3 8.0 0.031 0.0 NA
PO4
POL
POL
POL
PGE
HOH
 5.734
4.446
6.060
6.816
3.988
6.836
2.168
 C
O
HH2
C
HE1
HA
H
 NA
O2
H22
H12
H12
H2
O
1cjl 1 P07711 98.4 0.0 X-RAY
 1997-08-12 TRP A:281 A:189 6.0 0.024 B -106.0 22.3 6.0 0.024 0.0 HOH
 1.265
 H
 H1
3hwn 1 P07711 99.61 0.0 X-RAY
 2009-09-15 TRP A:227 A:189 62.0 0.243 B -105.3 24.8 62.0 0.243 0.0 BD3
HOH
 5.378
3.207
 NE1
N
 N25
O
TRP B:227 B:189 65.0 0.255 B -121.8 38.7 NA NA NA
TRP C:227 C:189 68.0 0.267 B -111.8 33.1 NA NA NA
TRP D:227 D:189 71.0 0.278 B -116.7 26.6 NA NA NA
3of8 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 TRP A:190 A:190 65.0 0.255 B -113.9 27.5 65.0 0.255 0.0 I0Y
HOH
 3.036
2.887
 CZ2
N
 C25
O
3of9 1 P07711 100.0 7e-167 X-RAY
 2010-12-08 TRP A:190 A:190 68.0 0.267 B -115.8 28.8 68.0 0.267 0.0 I0X
 3.458
 CZ2
 C23
2xu3 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 TRP A:189 A:189 61.0 0.239 B -115.1 22.9 61.0 0.239 0.0 XU3
BTB
CL
HOH
 4.789
2.527
4.927
2.037
 HE1
CG
HE1
H
 N20
H51
CL
O
2xu4 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 TRP A:189 A:189 60.0 0.235 B -116.2 23.0 60.0 0.235 0.0 DJT
GOL
GOL
HOH
 4.995
2.647
7.142
2.065
 HE1
HZ2
HA
H
 N9
H32
O2
O
2xu5 1 P07711 100.0 3e-166 X-RAY
 2011-01-12 TRP A:189 A:189 67.0 0.263 B -113.6 24.7 67.0 0.263 0.0 XU5
FLC
HOH
 5.624
3.518
2.816
 NE1
CE2
O
 N9
OG2
O
2yj2 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 TRP A:189 A:189 59.0 0.231 B -116.3 23.4 59.0 0.231 0.0 YJ2
GOL
HOH
 4.991
2.448
2.048
 HE1
HB3
H
 N35
H2
O
2yj8 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 TRP A:189 A:189 59.0 0.231 B -114.4 22.2 59.0 0.231 0.0 YJ8
GOL
HOH
 4.793
2.834
2.033
 HE1
CG
H
 N35
H2
O
2yj9 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 TRP A:189 A:189 60.0 0.235 B -116.1 22.4 60.0 0.235 0.0 YJ9
GOL
HOH
 4.765
2.523
2.124
 HE1
HA
H
 N9
O3
O
2yjb 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 TRP A:189 A:189 53.0 0.208 B -113.8 22.3 53.0 0.208 0.0 YJ9
GOL
HOH
 4.757
2.402
2.152
 HE1
HB3
HE1
 N9
H32
O
2yjc 1 P07711 100.0 3e-166 X-RAY
 2011-11-23 TRP A:189 A:189 68.0 0.267 B -113.6 20.2 68.0 0.267 0.0 424
HOH
 4.692
2.113
 HE1
H
 N16
O
3bc3 1 P07711 100.0 3e-166 X-RAY
 2008-03-18 TRP A:189 A:189 69.0 0.271 B -111.9 21.4 69.0 0.271 0.0 OPT
HOH
 3.021
2.739
 NE1
O
 O3
O
TRP B:189 B:189 64.0 0.251 B -113.0 24.3 NA NA NA
3h89 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 TRP A:189 A:189 64.0 0.251 B -115.7 25.3 64.0 0.251 0.0 NSX
HOH
 3.041
2.662
 NE1
N
 O3
O
TRP B:189 B:189 65.0 0.255 B -116.2 27.0 NA NA NA
TRP C:189 C:189 62.0 0.243 B -117.4 28.0 NA NA NA
TRP D:189 D:189 65.0 0.255 B -112.2 19.4 NA NA NA
TRP E:189 E:189 63.0 0.247 B -107.9 19.2 NA NA NA
TRP F:189 F:189 61.0 0.239 B -110.1 27.0 NA NA NA
3h8b 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 TRP A:189 A:189 60.0 0.235 B -113.3 24.7 60.0 0.235 0.0 NSY
HOH
 3.314
2.761
 NE1
O
 O3
O
TRP B:189 B:189 62.0 0.243 B -113.5 25.8 NA NA NA
TRP C:189 C:189 59.0 0.231 B -113.1 24.6 NA NA NA
TRP D:189 D:189 60.0 0.235 B -113.9 23.1 NA NA NA
TRP E:189 E:189 62.0 0.243 B -113.5 24.3 NA NA NA
TRP F:189 F:189 63.0 0.247 B -115.3 24.9 NA NA NA
3h8c 1 P07711 100.0 3e-166 X-RAY
 2009-10-20 TRP A:189 A:189 64.0 0.251 B -113.9 12.4 64.0 0.251 0.0 NSZ
HOH
 3.808
3.032
 O
N
 C10
O
TRP B:189 B:189 68.0 0.267 B -111.6 18.6 NA NA NA
4axl 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 TRP A:189 A:189 64.0 0.251 B -113.0 26.1 15.0 0.059 0.192 A:P07711:0.192
 ZN
GOL
GOL
HOH
 4.684
2.717
7.787
2.893
 NE1
O
CE3
N
 ZN
O3
O1
O
4axm 1 P07711 100.0 3e-166 X-RAY
 2013-05-08 TRP A:189 A:189 59.0 0.231 B -127.5 23.1 59.0 0.231 0.0 GOL
V65
HOH
 4.125
6.304
2.728
 CD1
NE1
N
 C2
N2
O
TRP B:189 B:189 61.0 0.239 B -115.3 28.4 NA NA NA
TRP C:189 F:189 57.0 0.224 B -121.0 23.8 NA NA NA
TRP D:189 I:189 58.0 0.227 B -121.0 44.0 NA NA NA
TRP E:189 L:189 54.0 0.212 B -111.7 31.4 NA NA NA
TRP F:189 O:189 56.0 0.22 B -110.3 27.3 NA NA NA
5f02 1 P07711 100.0 3e-166 X-RAY
 2016-02-24 TRP A:189 A:189 67.0 0.263 B -115.4 22.2 67.0 0.263 0.0 GOL
5T9
HOH
 2.346
4.977
2.065
 HA
HE1
H
 H11
N12
O
5mae 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 TRP A:189 A:189 67.0 0.263 B -110.1 21.3 67.0 0.263 0.0 7KN
EDO
HOH
 5.818
3.767
2.617
 NE1
CZ2
O
 N7
O2
O
5maj 1 P07711 100.0 3e-166 X-RAY
 2017-01-11 TRP A:189 A:189 65.0 0.255 B -113.8 23.7 65.0 0.255 0.0 7KH
HOH
 5.868
2.649
 NE1
O
 N7
O
5mqy 1 P07711 100.0 3e-166 X-RAY
 2017-03-22 TRP A:189 A:189 66.0 0.259 B -114.9 26.0 66.0 0.259 0.0 GH4
EDO
EDO
HOH
 5.754
8.099
3.631
2.856
 NE1
N
CZ2
N
 N23
O1
C2
O
6ezp 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 TRP A:189 A:189 65.0 0.255 B -113.8 23.7 65.0 0.255 0.0 C3E
GOL
GOL
HOH
 5.859
3.660
7.970
2.712
 NE1
CD1
C
O
 NAA
O2
O1
O
6ezx 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 TRP A:189 A:189 62.0 0.243 B -113.8 26.3 62.0 0.243 0.0 C7Q
HOH
 5.496
2.910
 NE1
N
 N19
O
TRP B:189 B:189 59.0 0.231 B -113.1 37.6 59.0 0.231 0.0 C7Q
HOH
 5.903
2.849
 NE1
N
 N19
O
6f06 1 P07711 100.0 3e-166 X-RAY
 2018-04-11 TRP A:189 A:189 53.0 0.208 B -114.5 21.1 53.0 0.208 0.0 C7T
ZN
CL
HOH
 6.715
5.104
3.724
2.935
 NE1
NE1
NE1
N
 N30
ZN
CL
O
TRP B:189 B:189 60.0 0.235 B -108.0 16.0 NA NA NA
2nqd 2 P07711 99.55 1e-165 X-RAY
 2007-07-24 TRP B:190 B:189 67.0 0.263 B -112.0 23.9 1.0 0.004 0.259 A:Q966X9:0.259
 HOH
 2.698
 O
 O
2xu1 1 P07711 99.55 2e-165 X-RAY
 2011-01-12 TRP A:189 A:189 64.0 0.251 B -113.6 20.5 64.0 0.251 0.0 424
HOH
 5.736
2.847
 NE1
N
 N16
O
TRP B:189 B:189 63.0 0.247 B -114.0 24.1 NA NA NA
TRP C:189 C:189 66.0 0.259 B -120.3 25.0 NA NA NA
TRP D:189 D:189 62.0 0.243 B -121.7 20.9 NA NA NA
3hha 1 P07711 99.55 2e-165 X-RAY
 2009-06-23 TRP A:189 A:189 63.0 0.247 B -114.6 22.5 63.0 0.247 0.0 NOW
PG4
ACT
HOH
 5.881
3.118
9.406
2.695
 NE1
NE1
CZ2
O
 N15
C5
CH3
O
TRP B:189 B:189 65.0 0.255 B -114.8 25.0 NA NA NA
TRP C:189 C:189 60.0 0.235 B -114.0 24.8 NA NA NA
TRP D:189 D:189 65.0 0.255 B -111.8 23.6 NA NA NA
3iv2 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 TRP A:189 A:189 62.0 0.243 B -109.3 24.4 62.0 0.243 0.0 GOL
SO4
SO4
HOH
 3.315
4.743
4.339
2.836
 NE1
NE1
O
N
 O2
O1
O2
O
TRP B:189 B:189 63.0 0.247 B -112.4 26.4 63.0 0.247 0.0 GOL
GOL
SO4
HOH
 3.830
4.191
4.842
3.995
 NE1
O
NE1
CA
 C3
O3
O2
O
3k24 1 P07711 99.55 5e-165 X-RAY
 2010-03-23 TRP A:189 A:189 61.0 0.239 B -115.5 28.3 61.0 0.239 0.0 HOH
 5.781
 N
 O
TRP B:189 B:189 65.0 0.255 B -110.7 29.9 NA NA NA
3kse 1 P07711 99.09 8e-165 X-RAY
 2010-12-01 TRP A:189 A:189 59.0 0.231 B -119.6 23.8 5.0 0.02 0.211 D:P01040:0.212
 HOH
 2.626
 O
 O
TRP B:189 B:189 65.0 0.255 B -118.0 23.9 NA NA NA
TRP C:189 C:189 58.0 0.227 B -119.6 23.5 NA NA NA
2vhs 1 P07711 91.82 1e-145 X-RAY
 2008-03-11 TRP A:186 A:189 62.0 0.243 B -114.6 26.3 62.0 0.243 0.0 SO4
HOH
 4.992
2.631
 NE1
O
 O2
O
TRP B:186 B:189 67.0 0.263 B -115.1 24.7 67.0 0.263 0.0 SO4
HOH
 4.978
2.623
 NE1
O
 O2
O
TRP C:186 C:189 63.0 0.247 B -116.3 24.5 63.0 0.247 0.0 SO4
HOH
 5.024
2.568
 NE1
O
 O2
O
TRP D:186 D:189 70.0 0.275 B -115.8 23.9 70.0 0.275 0.0 SO4
HOH
 5.059
2.573
 NE1
O
 O2
O
5i4h 2 P07711 99.11 9e-78 X-RAY
 2016-04-13 TRP B:81 B:189 102.0 0.4 S -110.4 29.2 66.0 0.259 0.141 A:P07711:0.141
 SO4
HOH
 4.462
1.935
 O
O
 O4
H2
1icf 2 P07711 100.0 1e-23 X-RAY
 2000-01-12 TRP B:11 B:189 161.0 0.631 S -113.7 27.6 1.0 0.004 0.627 A:P07711:0.384
E:P04233:0.408
 HOH
 2.686
 O
 O
TRP D:11 D:189 159.0 0.624 S -119.7 28.2 NA NA NA
1mhw 2 P07711 100.0 1e-23 X-RAY
 2002-12-11 TRP B:11 C:189 174.0 0.682 S -111.9 27.7 44.0 0.173 0.509 F:None:0.106
G:None:0.125
A:P07711:0.412
 HOH
 2.624
 O
 O
TRP D:11 D:189 174.0 0.682 S -116.3 27.1 NA NA NA

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p07711-f1 1 P07711 100.0 0.0 TRP A:302 A:302 6.0 0.024 B -109.0 22.8