Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chrX 133609216 . A C CCDS14641.1:NM_000194.2:c.140gAa>gCa_NP_000185.1:p.47E>A Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1bzy 1 P00492 100.0 3e-161 X-RAY
 1999-06-22 GLU A:46 A:46 111.0 0.584 H -62.6 -45.2 8.0 0.042 0.542 C:P00492:0.258
D:P00492:0.432
 HOH
 2.390
 OE1
 O
GLU B:46 B:46 106.0 0.558 H -62.1 -38.0 6.0 0.032 0.526 C:P00492:0.421
D:P00492:0.232
 HOH
 2.709
 O
 O
GLU C:46 C:46 108.0 0.568 H -59.3 -40.3 8.0 0.042 0.526 A:P00492:0.211
B:P00492:0.421
 HOH
 2.655
 OE2
 O
GLU D:46 D:46 107.0 0.563 H -63.0 -41.3 6.0 0.032 0.531 A:P00492:0.442
B:P00492:0.247
 HOH
 2.650
 O
 O
1hmp 1 P00492 100.0 3e-161 X-RAY
 1995-06-03 GLU A:46 A:46 108.0 0.568 H -63.0 -44.4 67.0 0.353 0.215 B:P00492:0.179
A:P00492:0.042
 HOH
 3.234
 OE1
 O
GLU B:46 B:46 105.0 0.553 H -59.8 -45.9 70.0 0.368 0.185 A:P00492:0.184
 HOH
 3.447
 OE1
 O
1z7g 1 P00492 100.0 3e-161 X-RAY
 2005-08-02 GLU A:46 A:46 65.0 0.342 H -62.4 -36.9 45.0 0.237 0.105 B:P00492:0.105
 HOH
 2.485
 OE1
 O
GLU B:46 B:46 66.0 0.347 H -62.3 -42.1 44.0 0.232 0.115 B:P00492:0.032
A:P00492:0.084
 HOH
 2.486
 OE1
 O
GLU C:46 C:46 64.0 0.337 H -67.1 -37.9 NA NA NA
GLU D:46 D:46 96.0 0.505 H -63.7 -39.1 NA NA NA
3gep 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 GLU A:46 A:46 106.0 0.558 H -58.7 -44.4 79.0 0.416 0.142 B:P00492:0.142
 HOH
 2.610
 OE1
 O
GLU B:46 B:46 104.0 0.547 H -57.7 -42.3 69.0 0.363 0.184 A:P00492:0.184
 HOH
 4.138
 CG
 O
3ggc 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 GLU A:46 A:46 104.0 0.547 H -57.6 -38.2 74.0 0.389 0.158 A:P00492:0.016
B:P00492:0.142
 HOH
 2.423
 OE1
 O
GLU B:46 B:46 103.0 0.542 H -65.6 -51.3 71.0 0.374 0.168 A:P00492:0.168
 HOH
 3.927
 OE1
 O
3ggj 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 GLU A:46 A:46 105.0 0.553 H -60.2 -42.5 79.0 0.416 0.137 B:P00492:0.137
 HOH
 2.732
 OE1
 O
GLU B:46 B:46 101.0 0.532 H -67.0 -53.8 71.0 0.374 0.158 A:P00492:0.158
 HOH
 4.215
 OE1
 O
4rab 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLU A:46 A:46 107.0 0.563 H -62.0 -42.5 8.0 0.042 0.521 D:P00492:0.453
B:P00492:0.2
 HOH
 2.285
 OE2
 O
GLU B:46 B:46 109.0 0.574 H -56.1 -48.6 12.0 0.063 0.511 C:P00492:0.453
A:P00492:0.142
 HOH
 2.978
 O
 O
GLU C:46 C:46 108.0 0.568 H -59.2 -43.2 8.0 0.042 0.526 D:P00492:0.2
B:P00492:0.463
 HOH
 2.766
 OE1
 O
GLU D:46 D:46 106.0 0.558 H -62.0 -42.9 5.0 0.026 0.532 C:P00492:0.2
A:P00492:0.463
 HOH
 2.231
 OE2
 O
4rac 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLU A:46 A:46 108.0 0.568 H -57.6 -45.9 11.0 0.058 0.51 D:P00492:0.432
B:P00492:0.216
 HOH
 2.746
 O
 O
GLU B:46 B:46 107.0 0.563 H -62.6 -45.7 12.0 0.063 0.5 C:P00492:0.437
A:P00492:0.163
 HOH
 2.621
 OE2
 O
GLU C:46 C:46 109.0 0.574 H -58.1 -47.1 32.0 0.168 0.406 D:P00492:0.153
B:P00492:0.316
 HOH
 2.598
 O
 O
GLU D:46 D:46 106.0 0.558 H -58.6 -45.7 11.0 0.058 0.5 C:P00492:0.142
A:P00492:0.437
 HOH
 2.535
 OE2
 O
4rad 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLU A:46 A:46 109.0 0.574 H -57.7 -46.1 10.0 0.053 0.521 D:P00492:0.463
B:P00492:0.2
 HOH
 2.695
 OE2
 O
GLU B:46 B:46 107.0 0.563 H -56.5 -49.1 11.0 0.058 0.505 C:P00492:0.458
A:P00492:0.189
 HOH
 2.618
 O
 O
GLU C:46 C:46 105.0 0.553 H -59.8 -50.1 7.0 0.037 0.516 D:P00492:0.2
B:P00492:0.463
 HOH
 2.367
 OE2
 O
GLU D:46 D:46 104.0 0.547 H -59.5 -48.8 12.0 0.063 0.484 C:P00492:0.184
A:P00492:0.426
 HOH
 2.655
 O
 O
GLU E:46 E:46 100.0 0.526 H -62.0 -42.7 NA NA NA
GLU F:46 F:46 109.0 0.574 H -58.5 -46.6 NA NA NA
GLU G:46 G:46 107.0 0.563 H -64.0 -48.6 NA NA NA
GLU H:46 H:46 107.0 0.563 H -63.7 -44.5 NA NA NA
4ran 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLU A:46 A:46 111.0 0.584 H -62.2 -45.1 20.0 0.105 0.479 D:P00492:0.368
B:P00492:0.179
GLU B:46 B:46 108.0 0.568 H -60.9 -44.0 10.0 0.053 0.515 C:P00492:0.437
A:P00492:0.174
 HOH
 5.948
 OE2
 O
GLU C:46 C:46 108.0 0.568 H -60.8 -47.7 9.0 0.047 0.521 D:P00492:0.179
B:P00492:0.453
 HOH
 6.979
 OE1
 O
GLU D:46 D:46 96.0 0.505 H -58.2 -46.4 7.0 0.037 0.468 C:P00492:0.137
A:P00492:0.411
 HOH
 5.620
 OE2
 O
4rao 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLU A:46 A:46 109.0 0.574 H -59.1 -45.0 9.0 0.047 0.527 D:P00492:0.458
B:P00492:0.211
 HOH
 2.494
 OE2
 O
GLU B:46 B:46 108.0 0.568 H -57.0 -44.8 11.0 0.058 0.51 C:P00492:0.447
A:P00492:0.158
 HOH
 2.519
 OE2
 O
GLU C:46 C:46 108.0 0.568 H -55.1 -44.1 8.0 0.042 0.526 D:P00492:0.158
B:P00492:0.453
 HOH
 2.594
 O
 O
GLU D:46 D:46 108.0 0.568 H -59.5 -43.6 10.0 0.053 0.515 A:P00492:0.437
C:P00492:0.221
 HOH
 2.755
 O
 O
4raq 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLU A:46 A:46 103.0 0.542 H -56.5 -49.9 9.0 0.047 0.495 D:P00492:0.416
B:P00492:0.211
 HOH
 2.809
 OE2
 O
GLU B:46 B:46 111.0 0.584 H -55.8 -48.1 8.0 0.042 0.542 A:P00492:0.232
C:P00492:0.442
 HOH
 2.617
 OE2
 O
GLU C:46 C:46 103.0 0.542 H -56.6 -45.5 9.0 0.047 0.495 D:P00492:0.211
B:P00492:0.416
 HOH
 2.913
 OE2
 O
GLU D:46 D:46 106.0 0.558 H -56.0 -37.4 12.0 0.063 0.495 C:P00492:0.195
A:P00492:0.442
 HOH
 2.534
 OE2
 O
4ijq 1 P00492 100.0 4e-161 X-RAY
 2013-03-27 GLU A:52 A:46 109.0 0.574 H -58.3 -44.4 10.0 0.053 0.521 D:P00492:0.453
B:P00492:0.205
 HOH
 2.453
 OE2
 O
GLU B:52 B:46 110.0 0.579 H -59.2 -42.8 10.0 0.053 0.526 C:P00492:0.453
A:P00492:0.163
 HOH
 2.325
 OE2
 O
GLU C:52 C:46 115.0 0.605 H -51.3 -45.6 12.0 0.063 0.542 D:P00492:0.2
B:P00492:0.458
 HOH
 2.588
 OE2
 O
GLU D:52 D:46 109.0 0.574 H -56.4 -44.2 10.0 0.053 0.521 A:P00492:0.442
C:P00492:0.168
 HOH
 2.296
 OE1
 O
4kn6 1 P00492 100.0 1e-160 X-RAY
 2013-08-14 GLU A:45 A:46 70.0 0.368 H -55.6 -49.7 70.0 0.368 0.0 HOH
 2.586
 OE2
 O
6bnj 1 P00492 99.08 6e-160 X-RAY
 2017-12-06 GLU A:47 A:46 108.0 0.568 H -58.4 -44.0 10.0 0.053 0.515 D:P00492:0.447
B:P00492:0.205
 HOH
 2.778
 O
 O
GLU B:47 B:46 106.0 0.558 H -56.7 -46.1 10.0 0.053 0.505 C:P00492:0.437
A:P00492:0.2
 HOH
 2.532
 OE2
 O
GLU C:47 C:46 104.0 0.547 H -52.5 -48.2 11.0 0.058 0.489 D:P00492:0.184
B:P00492:0.442
 HOH
 2.748
 OE2
 O
GLU D:47 D:46 109.0 0.574 H -54.3 -46.8 8.0 0.042 0.532 A:P00492:0.458
C:P00492:0.221
 HOH
 2.617
 OE2
 O
5hia 1 P00492 99.08 8e-160 X-RAY
 2017-01-18 GLU A:53 A:46 108.0 0.568 H -54.3 -45.7 10.0 0.053 0.515 D:P00492:0.453
B:P00492:0.211
 HOH
 2.656
 OE2
 O
GLU B:53 B:46 107.0 0.563 H -60.6 -43.7 9.0 0.047 0.516 A:P00492:0.205
C:P00492:0.453
 HOH
 2.429
 OE2
 O
GLU C:53 C:46 105.0 0.553 H -55.4 -43.7 8.0 0.042 0.511 D:P00492:0.195
B:P00492:0.447
 HOH
 2.646
 OE1
 O
GLU D:53 D:46 108.0 0.568 H -58.2 -44.9 7.0 0.037 0.531 A:P00492:0.458
C:P00492:0.211
 HOH
 2.784
 O
 O
5brn 1 P00492 98.62 3e-159 X-RAY
 2015-10-14 GLU A:47 A:46 104.0 0.547 H -60.7 -37.3 41.0 0.216 0.331 C:P00492:0.126
B:P00492:0.226
 HOH
 2.399
 O
 O
GLU B:47 B:46 99.0 0.521 H -57.0 -39.1 6.0 0.032 0.489 D:P00492:0.179
A:P00492:0.421
 HOH
 2.307
 OE2
 O
GLU C:47 C:46 102.0 0.537 H -57.2 -43.2 25.0 0.132 0.405 A:P00492:0.174
D:P00492:0.337
 HOH
 2.530
 OE2
 O
GLU D:47 D:46 105.0 0.553 H -59.3 -43.2 7.0 0.037 0.516 C:P00492:0.463
B:P00492:0.142
 HOH
 2.748
 OE2
 O
5bsk 1 P00492 98.62 3e-159 X-RAY
 2015-09-23 GLU A:47 A:46 67.0 0.353 H -61.7 -42.2 49.0 0.258 0.095 D:P00492:0.095
 HOH
 2.784
 OE2
 O
GLU B:47 B:46 74.0 0.389 H -63.6 -40.9 50.0 0.263 0.126 C:P00492:0.116
A:P00492:0.011
 HOH
 2.345
 O
 O
GLU C:47 C:46 62.0 0.326 H -62.0 -42.1 46.0 0.242 0.084 D:P00492:0.005
B:P00492:0.084
 HOH
 3.910
 OE2
 O
GLU D:47 D:46 81.0 0.426 H -62.0 -42.4 47.0 0.247 0.179 C:P00492:0.026
A:P00492:0.153
 HOH
 3.536
 OE2
 O
5w8v 1 P00492 100.0 7e-159 X-RAY
 2017-08-30 GLU A:44 A:46 102.0 0.537 H -60.3 -44.7 9.0 0.047 0.49 D:P00492:0.437
B:P00492:0.168
 HOH
 2.806
 O
 O
GLU B:44 B:46 103.0 0.542 H -57.4 -46.7 11.0 0.058 0.484 C:P00492:0.432
A:P00492:0.137
 HOH
 2.638
 O
 O
GLU C:44 C:46 102.0 0.537 H -59.6 -47.0 9.0 0.047 0.49 D:P00492:0.147
B:P00492:0.442
 HOH
 2.550
 OE1
 O
GLU D:44 D:46 102.0 0.537 H -59.0 -45.2 10.0 0.053 0.484 C:P00492:0.126
A:P00492:0.432
 HOH
 2.444
 OE2
 O
1d6n 1 P00492 99.07 6e-157 X-RAY
 1999-12-30 GLU A:43 A:46 80.0 0.421 H -18.1 -48.6 80.0 0.421 0.0 HOH
 4.470
 OE1
 O
GLU B:43 B:46 101.0 0.532 H -45.3 -18.2 101.0 0.532 0.0 HOH
 9.131
 O
 O
2vfa 1 P20035,P00492 80.48 3e-122 X-RAY
 2008-06-17 GLU A:55 A:55 104.0 0.547 H -59.1 -41.4 57.0 0.3 0.247 B:P20035+P00492:0.247
 HOH
 3.075
 OE1
 O
GLU B:55 B:55 104.0 0.547 H -58.5 -41.3 69.0 0.363 0.184 A:P20035+P00492:0.184
 HOH
 5.986
 OE1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00492-f1 1 P00492 100.0 2e-162 GLU A:47 A:47 67.0 0.353 H -56.3 -46.9