Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chrX 133609255 . A C CCDS14641.1:NM_000194.2:c.179cAt>cCt_NP_000185.1:p.60H>P Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1bzy 1 P00492 100.0 3e-161 X-RAY
 1999-06-22 HIS A:59 A:59 86.0 0.441 S -143.1 168.9 86.0 0.441 0.0 HOH
 6.866
 C
 O
HIS B:59 B:59 72.0 0.369 S -135.9 161.9 72.0 0.369 0.0 HOH
 2.690
 NE2
 O
HIS C:59 C:59 87.0 0.446 S -140.2 166.4 87.0 0.446 0.0 HOH
 4.491
 CE1
 O
HIS D:59 D:59 103.0 0.528 S -147.6 179.6 103.0 0.528 0.0 HOH
 9.862
 O
 O
1hmp 1 P00492 100.0 3e-161 X-RAY
 1995-06-03 HIS A:59 A:59 105.0 0.538 S -139.1 162.0 105.0 0.538 0.0 HOH
 2.943
 O
 O
HIS B:59 B:59 109.0 0.559 S -129.5 157.4 109.0 0.559 0.0 HOH
 2.719
 CB
 O
1z7g 1 P00492 100.0 3e-161 X-RAY
 2005-08-02 HIS A:59 A:59 123.0 0.631 S -132.8 168.5 123.0 0.631 0.0 HOH
 2.860
 O
 O
HIS B:59 B:59 111.0 0.569 S -130.6 173.5 111.0 0.569 0.0 HOH
 2.608
 O
 O
HIS C:59 C:59 101.0 0.518 S -142.5 -174.7 NA NA NA
HIS D:59 D:59 114.0 0.585 S -142.7 170.6 NA NA NA
3gep 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 HIS A:59 A:59 122.0 0.626 S -119.7 155.3 122.0 0.626 0.0 HOH
 3.117
 CB
 O
HIS B:59 NA:NA DO NA DO DO DO NA NA NA
3ggc 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 HIS A:59 A:59 103.0 0.528 S -65.7 163.5 103.0 0.528 0.0 HOH
 3.691
 CD2
 O
HIS B:59 NA:NA DO NA DO DO DO NA NA NA
3ggj 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 HIS A:59 A:59 102.0 0.523 S -56.5 164.7 102.0 0.523 0.0 HOH
 3.442
 CD2
 O
HIS B:59 NA:NA DO NA DO DO DO NA NA NA
4rab 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 HIS A:59 A:59 65.0 0.333 S -155.6 156.8 65.0 0.333 0.0 HOH
 4.256
 N
 O
HIS B:59 B:59 67.0 0.344 S -131.8 159.4 67.0 0.344 0.0 HOH
 6.790
 CE1
 O
HIS C:59 C:59 66.0 0.338 S -150.3 157.7 66.0 0.338 0.0 HOH
 3.401
 CB
 O
HIS D:59 D:59 79.0 0.405 S -154.9 155.8 79.0 0.405 0.0 HOH
 3.473
 ND1
 O
4rac 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 HIS A:59 A:59 96.0 0.492 S -147.9 150.6 96.0 0.492 0.0 HOH
 3.173
 CD2
 O
HIS B:59 B:59 105.0 0.538 S -126.7 159.8 105.0 0.538 0.0 HOH
 3.652
 CA
 O
HIS C:59 C:59 64.0 0.328 S -131.5 160.1 64.0 0.328 0.0 HOH
 5.723
 C
 O
HIS D:59 D:59 69.0 0.354 S -144.2 158.1 69.0 0.354 0.0
4rad 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 HIS A:59 A:59 70.0 0.359 S -159.0 159.4 70.0 0.359 0.0 HOH
 3.822
 HB3
 O
HIS B:59 B:59 69.0 0.354 S -150.5 148.5 69.0 0.354 0.0 HOH
 2.744
 HB2
 O
HIS C:59 C:59 60.0 0.308 S -158.8 159.1 60.0 0.308 0.0 HOH
 2.869
 ND1
 O
HIS D:59 D:59 62.0 0.318 S -155.1 164.1 62.0 0.318 0.0 HOH
 2.127
 HE2
 O
HIS E:59 E:59 72.0 0.369 S -152.0 163.5 NA NA NA
HIS F:59 F:59 101.0 0.518 S -111.9 151.2 NA NA NA
HIS G:59 G:59 72.0 0.369 S -129.6 168.4 NA NA NA
HIS H:59 H:59 67.0 0.344 S -161.4 158.8 NA NA NA
4ran 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 HIS A:59 A:59 76.0 0.39 S -134.2 166.2 76.0 0.39 0.0
HIS B:59 B:59 34.0 NA S -165.0 166.7 34.0 NA NA
HIS C:59 C:59 74.0 0.379 S -135.5 171.2 74.0 0.379 0.0
HIS D:59 D:59 108.0 0.554 S -139.8 168.4 108.0 0.554 0.0
4rao 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 HIS A:59 A:59 67.0 0.344 S -154.3 156.5 67.0 0.344 0.0 HOH
 3.633
 CB
 O
HIS B:59 B:59 71.0 0.364 S -114.0 170.9 71.0 0.364 0.0
HIS C:59 C:59 70.0 0.359 S -156.4 166.6 70.0 0.359 0.0 HOH
 9.440
 N
 O
HIS D:59 D:59 70.0 0.359 S -153.8 158.5 70.0 0.359 0.0 HOH
 3.690
 N
 O
4raq 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 HIS A:59 A:59 59.0 0.303 S -154.5 144.5 59.0 0.303 0.0
HIS B:59 B:59 107.0 0.549 S 178.4 179.0 107.0 0.549 0.0
HIS C:59 C:59 65.0 0.333 S -166.9 -172.5 65.0 0.333 0.0 HOH
 6.441
 O
 O
HIS D:59 D:59 66.0 0.338 S -135.4 162.3 66.0 0.338 0.0 HOH
 9.951
 N
 O
4ijq 1 P00492 100.0 4e-161 X-RAY
 2013-03-27 HIS A:65 A:59 102.0 0.523 S -151.7 159.7 102.0 0.523 0.0 HOH
 4.117
 CA
 O
HIS B:65 B:59 103.0 0.528 S -146.9 149.9 103.0 0.528 0.0 HOH
 2.853
 ND1
 O
HIS C:65 C:59 64.0 0.328 S -151.4 153.4 64.0 0.328 0.0 HOH
 3.592
 CB
 O
HIS D:65 D:59 66.0 0.338 S -153.5 159.4 66.0 0.338 0.0 HOH
 3.279
 CD2
 O
4kn6 1 P00492 100.0 1e-160 X-RAY
 2013-08-14 HIS A:58 A:59 109.0 0.559 S -120.2 120.8 109.0 0.559 0.0 HOH
 6.981
 O
 O
6bnj 1 P00492 99.08 6e-160 X-RAY
 2017-12-06 HIS A:60 A:59 64.0 0.328 S -144.8 151.7 64.0 0.328 0.0 HOH
 3.661
 C
 O
HIS B:60 B:59 70.0 0.359 S -151.3 155.1 70.0 0.359 0.0 HOH
 4.336
 N
 O
HIS C:60 C:59 65.0 0.333 S -150.8 151.2 65.0 0.333 0.0 HOH
 3.009
 NE2
 O
HIS D:60 D:59 72.0 0.369 S -153.4 155.3 72.0 0.369 0.0 HOH
 3.534
 CD2
 O
5hia 1 P00492 99.08 8e-160 X-RAY
 2017-01-18 HIS A:66 A:59 68.0 0.349 S -158.7 153.1 68.0 0.349 0.0 HOH
 3.397
 CB
 O
HIS B:66 B:59 65.0 0.333 S -154.0 153.4 65.0 0.333 0.0 HOH
 2.808
 NE2
 O
HIS C:66 C:59 65.0 0.333 S -151.0 154.3 65.0 0.333 0.0 HOH
 3.082
 NE2
 O
HIS D:66 D:59 69.0 0.354 S -152.5 158.7 69.0 0.354 0.0 HOH
 3.735
 CB
 O
5brn 1 P00492 98.62 3e-159 X-RAY
 2015-10-14 HIS A:60 A:59 65.0 0.333 S -157.1 160.3 65.0 0.333 0.0 HOH
 3.365
 CB
 O
HIS B:60 B:59 89.0 0.456 S -159.3 168.9 89.0 0.456 0.0 HOH
 2.999
 ND1
 O
HIS C:60 C:59 54.0 0.277 S -152.3 155.8 54.0 0.277 0.0 HOH
 3.203
 CE1
 O
HIS D:60 D:59 74.0 0.379 S -148.8 168.6 74.0 0.379 0.0 HOH
 3.101
 CD2
 O
5bsk 1 P00492 98.62 3e-159 X-RAY
 2015-09-23 HIS A:60 A:59 134.0 0.687 S -135.1 -143.2 134.0 0.687 0.0 HOH
 8.661
 O
 O
HIS B:60 B:59 97.0 0.497 S -127.6 155.5 97.0 0.497 0.0 HOH
 3.959
 CB
 O
HIS C:60 C:59 143.0 0.733 S -81.1 -157.7 143.0 0.733 0.0 HOH
 3.019
 O
 O
HIS D:60 D:59 86.0 0.441 S -132.3 172.6 86.0 0.441 0.0 HOH
 3.295
 CB
 O
5w8v 1 P00492 100.0 7e-159 X-RAY
 2017-08-30 HIS A:57 A:59 71.0 0.364 S -146.5 165.4 71.0 0.364 0.0 HOH
 3.561
 CD2
 O
HIS B:57 B:59 71.0 0.364 S -83.5 159.8 71.0 0.364 0.0 HOH
 7.745
 NE2
 O
HIS C:57 C:59 56.0 0.287 S -143.0 161.1 56.0 0.287 0.0 HOH
 3.644
 CB
 O
HIS D:57 D:59 68.0 0.349 S -159.9 162.0 68.0 0.349 0.0 HOH
 3.625
 CB
 O
1d6n 1 P00492 99.07 6e-157 X-RAY
 1999-12-30 HIS A:56 A:59 61.0 0.313 S -153.5 -170.8 61.0 0.313 0.0 HOH
 5.583
 CB
 O
HIS B:56 B:59 79.0 0.405 S -159.0 140.6 79.0 0.405 0.0 HOH
 2.789
 CE1
 O
2vfa 1 P20035,P00492 80.48 3e-122 X-RAY
 2008-06-17 HIS A:68 A:68 73.0 0.374 S -146.9 159.3 73.0 0.374 0.0 HOH
 2.995
 ND1
 O
HIS B:68 B:68 75.0 0.385 S -156.6 157.2 75.0 0.385 0.0 HOH
 4.459
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00492-f1 1 P00492 100.0 2e-162 HIS A:60 A:60 61.0 0.313 S -156.7 153.8