Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chrX 133609279 . T A CCDS14641.1:NM_000194.2:c.203cTc>cAc_NP_000185.1:p.68L>H Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1bzy 1 P00492 100.0 3e-161 X-RAY
 1999-06-22 LEU A:67 A:67 44.0 0.259 E -79.8 153.6 9.0 0.053 0.206 B:P00492:0.206
 MG
MG
IMU
POP
HOH
 4.229
7.569
5.753
3.795
2.936
 O
O
O
O
O
 MG
MG
O3'
O2
O
LEU B:67 B:67 47.0 0.276 E -76.1 151.6 10.0 0.059 0.217 A:P00492:0.218
 MG
MG
IMU
POP
HOH
 4.346
7.422
5.824
3.823
2.896
 O
O
O
C
O
 MG
MG
O3'
O1
O
LEU C:67 C:67 46.0 0.271 E -73.7 152.3 11.0 0.065 0.206 D:P00492:0.206
 MG
MG
IMU
POP
HOH
 4.234
7.340
5.872
3.542
2.861
 O
C
O
C
O
 MG
MG
O3'
O1
O
LEU D:67 D:67 47.0 0.276 E -73.7 153.8 7.0 0.041 0.235 C:P00492:0.235
 MG
MG
IMU
POP
HOH
 4.227
7.709
5.880
3.760
2.668
 O
C
O
C
O
 MG
MG
O3'
O2
O
1hmp 1 P00492 100.0 3e-161 X-RAY
 1995-06-03 LEU A:67 A:67 39.0 0.229 -93.7 67.4 18.0 0.106 0.123 B:P00492:0.124
 5GP
HOH
 6.959
4.181
 C
CA
 O2'
O
LEU B:67 B:67 90.0 0.529 T -72.2 12.1 63.0 0.371 0.158 A:P00492:0.159
 5GP
HOH
 7.904
9.378
 C
O
 O2'
O
1z7g 1 P00492 100.0 3e-161 X-RAY
 2005-08-02 LEU A:67 A:67 40.0 0.235 -67.1 127.1 17.0 0.1 0.135 B:P00492:0.135
 HOH
 3.929
 C
 O
LEU B:67 B:67 43.0 0.253 -66.2 121.2 17.0 0.1 0.153 A:P00492:0.153
 HOH
 2.836
 O
 O
LEU C:67 C:67 83.0 0.488 -65.9 122.5 NA NA NA
LEU D:67 D:67 44.0 0.259 -66.8 115.7 NA NA NA
3gep 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 LEU A:67 A:67 32.0 0.188 E -93.8 114.8 0.0 0.0 0.188 B:P00492:0.188
 24H
HOH
 8.461
4.041
 C
C
 OAD
O
LEU B:67 B:67 41.0 0.241 E -74.2 163.6 5.0 0.029 0.212 A:P00492:0.212
 24H
HOH
 9.223
4.805
 O
O
 OAD
O
3ggc 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 LEU A:67 A:67 36.0 0.212 E -95.4 100.1 0.0 0.0 0.212 B:P00492:0.212
 HOH
 3.670
 C
 O
LEU B:67 B:67 44.0 0.259 E -75.8 166.8 5.0 0.029 0.23 A:P00492:0.229
 HOH
 3.476
 CD1
 O
3ggj 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 LEU A:67 A:67 34.0 0.2 E -105.4 96.8 0.0 0.0 0.2 B:P00492:0.2
 HOH
 3.498
 C
 O
LEU B:67 B:67 42.0 0.247 E -80.2 171.6 4.0 0.024 0.223 A:P00492:0.224
 HOH
 3.534
 CD1
 O
4rab 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 LEU A:67 A:67 69.0 0.406 E -71.9 154.6 25.0 0.147 0.259 C:P00492:0.259
 3L3
MG
PO4
HOH
 7.167
6.935
3.578
2.799
 O
O
C
O
 CAL
MG
O4
O
LEU B:67 B:67 61.0 0.359 T -71.5 155.3 19.0 0.112 0.247 D:P00492:0.247
 3L3
MG
PO4
HOH
 6.909
6.069
3.796
3.505
 O
O
C
O
 OAD
MG
O4
O
LEU C:67 C:67 46.0 0.271 E -65.0 153.3 14.0 0.082 0.189 A:P00492:0.188
 3L3
MG
MG
PO4
HOH
 7.625
6.353
7.733
3.987
4.281
 O
O
O
O
O
 OAH
MG
MG
O2
O
LEU D:67 D:67 60.0 0.353 E -68.1 153.2 19.0 0.112 0.241 B:P00492:0.241
 3L3
MG
MG
PO4
HOH
 7.050
5.407
8.733
3.368
2.963
 O
O
O
O
O
 CAL
MG
MG
O2
O
4rac 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 LEU A:67 A:67 56.0 0.329 E -71.2 154.9 16.0 0.094 0.235 C:P00492:0.235
 3L4
MG
MG
HOH
 3.690
7.787
5.288
2.541
 C
O
O
O
 OAG
MG
MG
O
LEU B:67 B:67 50.0 0.294 E -70.0 154.7 16.0 0.094 0.2 D:P00492:0.2
 3L4
MG
MG
HOH
 3.655
7.771
5.469
2.574
 O
O
O
O
 OAG
MG
MG
O
LEU C:67 C:67 55.0 0.324 E -75.9 156.2 15.0 0.088 0.236 A:P00492:0.235
 3L4
MG
MG
HOH
 3.688
5.245
7.894
2.743
 O
O
O
O
 OAH
MG
MG
O
LEU D:67 D:67 51.0 0.3 E -65.7 152.2 18.0 0.106 0.194 B:P00492:0.194
 3L4
MG
HOH
 3.757
5.407
3.143
 C
O
O
 OAG
MG
O
4rad 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 LEU A:67 A:67 61.0 0.359 T -74.3 154.4 22.0 0.129 0.23 C:P00492:0.229
 3L5
MG
HOH
 3.790
7.521
2.687
 O
O
O
 OAF
MG
O
LEU B:67 B:67 58.0 0.341 E -78.2 154.5 19.0 0.112 0.229 D:P00492:0.229
 3L5
MG
MG
HOH
 5.394
8.155
8.097
2.722
 O
O
O
O
 H3
MG
MG
O
LEU C:67 C:67 47.0 0.276 E -66.9 155.7 14.0 0.082 0.194 A:P00492:0.194
 3L5
MG
HOH
 3.786
5.522
3.625
 C
O
O
 OAF
MG
O
LEU D:67 D:67 59.0 0.347 E -66.5 158.1 19.0 0.112 0.235 B:P00492:0.235
 3L5
MG
HOH
 3.024
5.136
2.632
 O
O
O
 H4
MG
O
LEU E:67 E:67 58.0 0.341 E -80.8 156.5 NA NA NA
LEU F:67 F:67 46.0 0.271 E -75.7 157.1 NA NA NA
LEU G:67 G:67 53.0 0.312 E -72.2 161.4 NA NA NA
LEU H:67 H:67 54.0 0.318 E -65.6 154.6 NA NA NA
4ran 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 LEU A:67 A:67 60.0 0.353 E -69.8 152.7 20.0 0.118 0.235 C:P00492:0.235
 3L6
MG
HOH
 7.225
5.268
3.582
 O
O
O
 CAI
MG
O
LEU B:67 B:67 52.0 0.306 T -75.1 152.5 17.0 0.1 0.206 D:P00492:0.206
 3L6
MG
HOH
 7.615
4.779
3.372
 O
O
O
 CAI
MG
O
LEU C:67 C:67 46.0 0.271 T -68.6 149.0 11.0 0.065 0.206 A:P00492:0.206
 3L6
MG
HOH
 5.475
5.785
5.356
 O
O
O
 NAA
MG
O
LEU D:67 D:67 56.0 0.329 E -77.6 149.8 15.0 0.088 0.241 B:P00492:0.241
 3L6
MG
 5.163
5.645
 O
O
 NAA
MG
4rao 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 LEU A:67 A:67 59.0 0.347 E -71.6 155.5 14.0 0.082 0.265 C:P00492:0.265
 3L7
MG
MG
HOH
 3.749
5.277
8.128
2.540
 C
O
O
O
 OAE
MG
MG
O
LEU B:67 B:67 57.0 0.335 E -79.6 158.9 15.0 0.088 0.247 D:P00492:0.247
 3L7
MG
MG
HOH
 3.845
5.401
8.087
4.520
 C
O
O
CD1
 OAB
MG
MG
O
LEU C:67 C:67 46.0 0.271 E -68.8 155.7 14.0 0.082 0.189 A:P00492:0.188
 3L7
MG
MG
HOH
 3.712
5.493
7.986
2.510
 C
O
O
O
 OAE
MG
MG
O
LEU D:67 D:67 64.0 0.376 T -69.9 160.0 22.0 0.129 0.247 B:P00492:0.247
 3L7
MG
MG
HOH
 3.700
5.159
8.015
3.334
 O
O
O
O
 OAD
MG
MG
O
4raq 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 LEU A:67 A:67 54.0 0.318 E -68.7 149.6 17.0 0.1 0.218 C:P00492:0.218
 3L8
MG
MG
HOH
 3.780
7.980
4.983
2.942
 O
O
O
O
 OAC
MG
MG
O
LEU B:67 B:67 49.0 0.288 E -64.1 159.3 13.0 0.076 0.212 D:P00492:0.212
 3L8
MG
MG
HOH
 3.763
8.799
5.475
3.648
 O
O
O
O
 OAF
MG
MG
O
LEU C:67 C:67 49.0 0.288 E -60.3 148.5 15.0 0.088 0.2 A:P00492:0.2
 3L8
MG
MG
HOH
 3.858
9.087
5.683
3.533
 C
O
O
O
 OAG
MG
MG
O
LEU D:67 D:67 58.0 0.341 E -64.9 150.7 22.0 0.129 0.212 B:P00492:0.212
 3L8
MG
MG
HOH
 3.375
5.144
8.166
3.241
 O
O
O
O
 OAG
MG
MG
O
4ijq 1 P00492 100.0 4e-161 X-RAY
 2013-03-27 LEU A:73 A:67 55.0 0.324 E -67.2 156.2 17.0 0.1 0.224 C:P00492:0.224
 SV2
SO4
MG
MG
HOH
 7.586
3.784
5.226
7.843
3.500
 O
O
O
O
O
 CAL
O3
MG
MG
O
LEU B:73 B:67 57.0 0.335 E -72.4 158.9 19.0 0.112 0.223 D:P00492:0.224
 SV2
MG
SO4
MG
HOH
 7.169
5.407
3.711
7.773
2.628
 O
O
O
O
O
 CAL
MG
O3
MG
O
LEU C:73 C:67 52.0 0.306 T -68.2 160.0 18.0 0.106 0.2 A:P00492:0.2
 SV2
MG
MG
SO4
HOH
 7.136
5.467
8.683
3.711
3.596
 O
O
C
O
O
 CAL
MG
MG
O2
O
LEU D:73 D:67 57.0 0.335 T -70.4 157.5 20.0 0.118 0.217 B:P00492:0.218
 MG
SV2
MG
SO4
HOH
 7.967
7.313
5.359
3.839
2.868
 O
O
O
O
O
 MG
CAL
MG
O1
O
4kn6 1 P00492 100.0 1e-160 X-RAY
 2013-08-14 LEU A:66 A:67 47.0 0.276 E -122.3 117.6 47.0 0.276 0.0 1RP
HOH
 8.505
4.759
 C
HA
 O2'
O
6bnj 1 P00492 99.08 6e-160 X-RAY
 2017-12-06 LEU A:68 A:67 55.0 0.324 E -77.0 155.3 13.0 0.076 0.248 C:P00492:0.247
 WPG
MG
MG
HOH
 3.810
5.710
7.883
2.932
 C
O
O
O
 OAH
MG
MG
O
LEU B:68 B:67 60.0 0.353 E -73.9 157.0 18.0 0.106 0.247 D:P00492:0.247
 WPG
MG
MG
HOH
 3.843
5.249
8.072
2.831
 O
O
O
O
 OAG
MG
MG
O
LEU C:68 C:67 51.0 0.3 T -64.9 158.0 19.0 0.112 0.188 A:P00492:0.188
 WPG
MG
MG
HOH
 3.674
5.448
7.700
2.845
 C
O
O
O
 OAG
MG
MG
O
LEU D:68 D:67 60.0 0.353 E -79.2 157.8 20.0 0.118 0.235 B:P00492:0.235
 WPG
MG
MG
HOH
 3.851
5.676
7.961
2.928
 O
O
O
O
 OAG
MG
MG
O
5hia 1 P00492 99.08 8e-160 X-RAY
 2017-01-18 LEU A:74 A:67 56.0 0.329 E -80.9 154.3 14.0 0.082 0.247 C:P00492:0.247
 YPG
MG
MG
HOH
 3.804
7.869
5.642
2.924
 C
C
O
O
 OAG
MG
MG
O
LEU B:74 B:67 63.0 0.371 T -71.4 157.5 22.0 0.129 0.242 D:P00492:0.241
 YPG
MG
MG
HOH
 3.689
7.695
5.327
2.717
 O
O
O
O
 OAH
MG
MG
O
LEU C:74 C:67 56.0 0.329 T -73.4 155.2 21.0 0.124 0.205 A:P00492:0.206
 YPG
MG
MG
HOH
 3.638
7.703
5.446
3.028
 C
O
O
O
 OAG
MG
MG
O
LEU D:74 D:67 61.0 0.359 E -70.3 157.7 21.0 0.124 0.235 B:P00492:0.235
 YPG
MG
MG
HOH
 3.800
7.827
5.380
2.754
 C
O
O
O
 OAG
MG
MG
O
5brn 1 P00492 98.62 3e-159 X-RAY
 2015-10-14 LEU A:68 A:67 62.0 0.365 T -77.0 154.4 18.0 0.106 0.259 D:P00492:0.259
 MG
4X2
HOH
 5.330
6.845
3.288
 O
O
O
 MG
O10
O
LEU B:68 B:67 60.0 0.353 E -77.3 152.1 17.0 0.1 0.253 C:P00492:0.253
 MG
4X2
HOH
 5.416
6.730
3.748
 O
O
O
 MG
O10
O
LEU C:68 C:67 50.0 0.294 T -69.8 154.3 14.0 0.082 0.212 B:P00492:0.212
 MG
4X2
HOH
 5.566
6.692
2.767
 O
O
O
 MG
O10
O
LEU D:68 D:67 71.0 0.418 E -65.8 153.1 29.0 0.171 0.247 A:P00492:0.247
 MG
4X2
HOH
 5.334
6.740
3.522
 O
O
O
 MG
O10
O
5bsk 1 P00492 98.62 3e-159 X-RAY
 2015-09-23 LEU A:68 A:67 80.0 0.471 S -113.2 145.0 47.0 0.276 0.195 C:P00492:0.194
 4X7
MG
HOH
 7.564
5.812
4.881
 C
C
C
 OAD
MG
O
LEU B:68 B:67 76.0 0.447 S -108.7 150.9 42.0 0.247 0.2 D:P00492:0.2
 4X7
MG
HOH
 8.260
5.586
4.016
 C
C
N
 OAD
MG
O
LEU C:68 C:67 77.0 0.453 E -102.2 145.4 41.0 0.241 0.212 A:P00492:0.212
 4X7
MG
HOH
 8.532
6.074
4.444
 C
C
C
 OAD
MG
O
LEU D:68 D:67 71.0 0.418 S -93.4 147.3 38.0 0.224 0.194 B:P00492:0.194
 4X7
MG
HOH
 7.812
6.368
4.193
 C
C
O
 OAD
MG
O
5w8v 1 P00492 100.0 7e-159 X-RAY
 2017-08-30 LEU A:65 A:67 68.0 0.4 E -68.2 154.7 26.0 0.153 0.247 C:P00492:0.247
 9YP
MG
HOH
 5.097
5.555
3.373
 O
O
O
 OAF
MG
O
LEU B:65 B:67 56.0 0.329 E -66.3 151.2 19.0 0.112 0.217 D:P00492:0.218
 9YP
MG
HOH
 4.992
5.794
3.096
 O
O
O
 OAE
MG
O
LEU C:65 C:67 52.0 0.306 T -60.8 149.5 17.0 0.1 0.206 A:P00492:0.206
 9YP
MG
HOH
 4.884
5.973
2.965
 O
O
O
 OAC
MG
O
LEU D:65 D:67 54.0 0.318 T -61.6 150.6 18.0 0.106 0.212 B:P00492:0.212
 9YP
MG
HOH
 4.981
5.776
3.750
 O
O
O
 OAC
MG
O
1d6n 1 P00492 99.07 6e-157 X-RAY
 1999-12-30 LEU A:64 A:67 47.0 0.276 -160.0 175.7 18.0 0.106 0.17 B:P00492:0.171
 MG
PRP
HOH
 5.714
2.460
3.738
 N
C
N
 MG
O3B
O
LEU B:64 B:67 80.0 0.471 -98.3 -151.1 23.0 0.135 0.336 A:P00492:0.335
 MG
PPO
PRP
HOH
 4.128
9.283
4.450
2.809
 O
O
O
O
 MG
C2
O2
O
2vfa 1 P20035,P00492 80.48 3e-122 X-RAY
 2008-06-17 LEU A:76 A:76 82.0 0.482 -78.0 107.8 82.0 0.482 0.0 5GP
SO4
HOH
 7.298
9.023
4.723
 O
O
C
 O3'
O1
O
LEU B:76 B:76 40.0 0.235 -66.4 92.8 40.0 0.235 0.0 5GP
SO4
HOH
 6.055
9.287
4.428
 O
O
O
 O3'
O4
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00492-f1 1 P00492 100.0 2e-162 LEU A:68 A:68 60.0 0.353 E -91.2 151.1