Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chrX 133609285 . G A CCDS14641.1:NM_000194.2:c.209gGg>gAg_NP_000185.1:p.70G>E Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1bzy 1 P00492 100.0 3e-161 X-RAY
 1999-06-22 GLY A:69 A:69 7.0 0.093 T -48.7 -42.4 7.0 0.093 0.0 MG
MG
IMU
POP
HOH
 4.108
5.858
4.343
2.785
2.752
 N
N
CA
N
O
 MG
MG
O2'
O2
O
GLY B:69 B:69 7.0 0.093 T -46.9 -28.9 7.0 0.093 0.0 MG
MG
IMU
POP
HOH
 4.228
5.630
4.330
2.816
2.607
 N
N
CA
N
O
 MG
MG
O2'
O2
O
GLY C:69 C:69 7.0 0.093 T -53.1 -30.6 7.0 0.093 0.0 MG
MG
IMU
POP
HOH
 4.021
5.495
4.432
2.939
2.627
 N
N
CA
N
O
 MG
MG
O2'
O2
O
GLY D:69 D:69 7.0 0.093 T -50.9 -29.6 7.0 0.093 0.0 MG
MG
IMU
POP
HOH
 4.254
5.882
4.366
2.802
2.662
 N
N
CA
N
O
 MG
MG
O2'
O2
O
1hmp 1 P00492 100.0 3e-161 X-RAY
 1995-06-03 GLY A:69 A:69 18.0 0.24 S -109.1 11.7 13.0 0.173 0.067 B:P00492:0.067
 5GP
HOH
 5.166
4.548
 N
N
 O2'
O
GLY B:69 B:69 33.0 0.44 S 107.5 32.9 18.0 0.24 0.2 A:P00492:0.2
 5GP
HOH
 7.136
7.662
 N
O
 O2'
O
1z7g 1 P00492 100.0 3e-161 X-RAY
 2005-08-02 GLY A:69 A:69 38.0 0.507 S 121.4 -24.9 22.0 0.293 0.214 B:P00492:0.213
 HOH
 3.260
 O
 O
GLY B:69 B:69 35.0 0.467 S 124.1 -36.3 22.0 0.293 0.174 A:P00492:0.173
 HOH
 3.246
 C
 O
GLY C:69 C:69 38.0 0.507 S 112.4 -18.9 NA NA NA
GLY D:69 D:69 34.0 0.453 S 126.4 -34.8 NA NA NA
3gep 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 GLY A:69 A:69 38.0 0.507 S -79.3 -46.8 25.0 0.333 0.174 B:P00492:0.173
 24H
HOH
 7.226
3.223
 N
C
 OAD
O
GLY B:69 B:69 31.0 0.413 T -36.4 -35.5 31.0 0.413 0.0 24H
HOH
 7.983
3.268
 CA
O
 OAD
O
3ggc 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 GLY A:69 A:69 43.0 0.573 S -102.8 -21.9 26.0 0.347 0.226 B:P00492:0.227
 H26
HOH
 8.955
2.916
 N
C
 CAG
O
GLY B:69 B:69 35.0 0.467 T -67.8 -53.5 35.0 0.467 0.0 H26
HOH
 8.954
3.502
 CA
O
 CAG
O
3ggj 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 GLY A:69 A:69 41.0 0.547 S -106.9 -34.5 24.0 0.32 0.227 B:P00492:0.227
 25H
HOH
 8.887
3.235
 N
C
 CAG
O
GLY B:69 B:69 31.0 0.413 T -52.0 -54.1 31.0 0.413 0.0 25H
HOH
 9.267
3.882
 CA
O
 CAG
O
4rab 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLY A:69 A:69 5.0 0.067 T -65.3 -21.7 5.0 0.067 0.0 3L3
MG
PO4
HOH
 7.385
6.454
2.994
2.437
 N
C
N
O
 OAH
MG
O1
O
GLY B:69 B:69 5.0 0.067 T -52.5 -29.2 5.0 0.067 0.0 3L3
MG
PO4
HOH
 7.571
5.893
2.640
2.596
 N
CA
N
O
 OAD
MG
O4
O
GLY C:69 C:69 5.0 0.067 T -53.5 -26.0 5.0 0.067 0.0 3L3
MG
MG
PO4
HOH
 7.559
5.839
6.380
3.130
2.598
 CA
CA
N
N
O
 N2
MG
MG
O2
O
GLY D:69 D:69 5.0 0.067 T -62.9 -18.4 5.0 0.067 0.0 3L3
MG
MG
PO4
HOH
 7.643
5.088
7.255
3.229
2.478
 CA
CA
N
N
O
 N2
MG
MG
O2
O
4rac 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLY A:69 A:69 4.0 0.053 T -63.9 -18.4 4.0 0.053 0.0 3L4
MG
MG
HOH
 2.844
6.556
5.161
2.844
 N
N
CA
O
 OAD
MG
MG
O
GLY B:69 B:69 3.0 0.04 T -63.2 -21.9 3.0 0.04 0.0 3L4
MG
MG
HOH
 2.756
6.633
5.362
2.757
 N
N
CA
O
 OAD
MG
MG
O
GLY C:69 C:69 5.0 0.067 T -63.1 -21.5 5.0 0.067 0.0 3L4
MG
MG
HOH
 2.765
5.373
6.708
2.638
 N
N
N
O
 OAG
MG
MG
O
GLY D:69 D:69 5.0 0.067 T -59.7 -22.7 5.0 0.067 0.0 3L4
MG
HOH
 2.818
5.343
2.791
 N
CA
O
 OAH
MG
O
4rad 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLY A:69 A:69 5.0 0.067 T -59.4 -23.3 5.0 0.067 0.0 3L5
MG
HOH
 2.436
7.375
2.741
 H
HA3
O
 OAF
MG
O
GLY B:69 B:69 4.0 0.053 T -62.2 -18.1 4.0 0.053 0.0 3L5
MG
MG
HOH
 4.906
7.718
6.191
2.368
 H
HA3
HA3
H
 H8
MG
MG
O
GLY C:69 C:69 7.0 0.093 T -63.7 -23.9 7.0 0.093 0.0 3L5
MG
HOH
 2.112
4.978
2.708
 H
HA3
O
 OAF
MG
O
GLY D:69 D:69 5.0 0.067 T -57.9 -15.9 5.0 0.067 0.0 3L5
MG
HOH
 1.859
4.961
2.530
 H
H
O
 H3
MG
O
GLY E:69 E:69 4.0 0.053 T -57.9 -20.2 NA NA NA
GLY F:69 F:69 4.0 0.053 T -66.1 -24.2 NA NA NA
GLY G:69 G:69 6.0 0.08 T -56.7 -22.1 NA NA NA
GLY H:69 H:69 5.0 0.067 T -63.9 -19.0 NA NA NA
4ran 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLY A:69 A:69 5.0 0.067 T -58.8 -24.3 5.0 0.067 0.0 3L6
MG
HOH
 7.437
5.661
3.679
 CA
N
N
 N2
MG
O
GLY B:69 B:69 5.0 0.067 T -60.5 -21.2 5.0 0.067 0.0 3L6
MG
HOH
 7.139
5.006
3.166
 CA
N
N
 N2
MG
O
GLY C:69 C:69 5.0 0.067 T -56.1 -20.0 5.0 0.067 0.0 3L6
MG
HOH
 7.274
5.922
4.452
 CA
N
CA
 N2
MG
O
GLY D:69 D:69 5.0 0.067 T -52.5 -29.0 5.0 0.067 0.0 3L6
MG
 7.065
5.219
 N
CA
 NAA
MG
4rao 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLY A:69 A:69 5.0 0.067 T -63.4 -24.0 5.0 0.067 0.0 3L7
MG
MG
HOH
 2.539
5.390
6.746
2.650
 N
CA
N
O
 OAE
MG
MG
O
GLY B:69 B:69 5.0 0.067 T -60.1 -25.3 5.0 0.067 0.0 3L7
MG
MG
HOH
 2.752
5.444
6.784
2.700
 N
CA
N
O
 OAD
MG
MG
O
GLY C:69 C:69 6.0 0.08 T -57.3 -24.5 6.0 0.08 0.0 3L7
MG
MG
HOH
 2.817
5.384
6.389
2.809
 N
CA
N
O
 OAD
MG
MG
O
GLY D:69 D:69 5.0 0.067 T -62.8 -24.5 5.0 0.067 0.0 3L7
MG
MG
HOH
 2.530
5.316
6.602
2.738
 N
CA
N
O
 OAB
MG
MG
O
4raq 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 GLY A:69 A:69 5.0 0.067 T -59.4 -27.8 5.0 0.067 0.0 3L8
MG
MG
HOH
 2.736
7.108
4.811
2.668
 N
N
CA
O
 OAC
MG
MG
O
GLY B:69 B:69 6.0 0.08 T -68.4 -15.2 6.0 0.08 0.0 3L8
MG
MG
HOH
 3.171
7.543
4.832
3.500
 N
N
CA
CA
 OAC
MG
MG
O
GLY C:69 C:69 4.0 0.053 T -52.7 -25.5 4.0 0.053 0.0 3L8
MG
MG
HOH
 3.355
7.733
6.133
3.479
 N
N
CA
N
 OAC
MG
MG
O
GLY D:69 D:69 4.0 0.053 T -68.2 -11.5 4.0 0.053 0.0 3L8
MG
MG
HOH
 3.367
4.929
6.783
2.384
 N
N
N
O
 OAG
MG
MG
O
4ijq 1 P00492 100.0 4e-161 X-RAY
 2013-03-27 GLY A:75 A:69 4.0 0.053 T -56.5 -26.0 4.0 0.053 0.0 SV2
SO4
MG
MG
HOH
 7.608
2.724
5.049
6.441
2.676
 N
N
CA
N
O
 CAL
O1
MG
MG
O
GLY B:75 B:69 5.0 0.067 T -61.1 -22.8 5.0 0.067 0.0 SV2
MG
SO4
MG
HOH
 7.472
5.265
2.615
6.429
2.835
 N
CA
N
N
O
 CAL
MG
O4
MG
O
GLY C:75 C:69 5.0 0.067 T -54.6 -28.8 5.0 0.067 0.0 SV2
MG
MG
SO4
HOH
 7.137
5.201
7.612
2.577
2.810
 N
CA
N
N
O
 OAC
MG
MG
O4
O
GLY D:75 D:69 5.0 0.067 T -64.6 -21.5 5.0 0.067 0.0 MG
SV2
MG
SO4
HOH
 6.586
7.483
5.270
2.730
2.657
 N
N
CA
N
O
 MG
CAL
MG
O1
O
4kn6 1 P00492 100.0 1e-160 X-RAY
 2013-08-14 GLY A:68 A:69 43.0 0.573 S -105.2 -18.5 43.0 0.573 0.0 1RP
HOH
 6.795
4.908
 H
O
 O2'
O
6bnj 1 P00492 99.08 6e-160 X-RAY
 2017-12-06 GLY A:70 A:69 6.0 0.08 T -58.4 -29.5 6.0 0.08 0.0 WPG
MG
MG
HOH
 3.096
5.231
6.249
2.897
 N
CA
N
O
 OAD
MG
MG
O
GLY B:70 B:69 6.0 0.08 T -62.5 -25.5 6.0 0.08 0.0 WPG
MG
MG
HOH
 3.094
5.251
6.449
2.867
 N
CA
N
O
 OAG
MG
MG
O
GLY C:70 C:69 6.0 0.08 T -62.8 -26.9 6.0 0.08 0.0 WPG
MG
MG
HOH
 3.059
5.116
6.188
2.955
 N
CA
N
O
 OAH
MG
MG
O
GLY D:70 D:69 7.0 0.093 T -64.7 -20.9 7.0 0.093 0.0 WPG
MG
MG
HOH
 3.050
5.226
6.241
2.798
 N
CA
N
O
 OAG
MG
MG
O
5hia 1 P00492 99.08 8e-160 X-RAY
 2017-01-18 GLY A:76 A:69 6.0 0.08 T -58.5 -29.3 6.0 0.08 0.0 YPG
MG
MG
HOH
 2.976
6.205
4.957
2.632
 N
N
CA
O
 OAH
MG
MG
O
GLY B:76 B:69 5.0 0.067 T -61.7 -26.2 5.0 0.067 0.0 YPG
MG
MG
HOH
 3.115
6.229
5.113
2.621
 N
N
CA
O
 OAH
MG
MG
O
GLY C:76 C:69 6.0 0.08 T -58.2 -28.2 6.0 0.08 0.0 YPG
MG
MG
HOH
 3.040
6.149
5.138
2.716
 N
N
CA
O
 OAH
MG
MG
O
GLY D:76 D:69 6.0 0.08 T -53.9 -30.1 6.0 0.08 0.0 YPG
MG
MG
HOH
 2.986
6.142
4.849
2.721
 N
N
CA
O
 OAH
MG
MG
O
5brn 1 P00492 98.62 3e-159 X-RAY
 2015-10-14 GLY A:70 A:69 6.0 0.08 T -57.4 -31.8 6.0 0.08 0.0 MG
4X2
HOH
 5.351
6.391
2.581
 CA
CA
O
 MG
O10
O
GLY B:70 B:69 5.0 0.067 T -55.9 -20.1 5.0 0.067 0.0 MG
4X2
HOH
 5.470
6.067
2.324
 N
CA
O
 MG
O10
O
GLY C:70 C:69 7.0 0.093 T -59.1 -20.5 7.0 0.093 0.0 MG
4X2
HOH
 5.468
6.025
2.875
 CA
CA
O
 MG
O10
O
GLY D:70 D:69 5.0 0.067 T -57.0 -13.5 5.0 0.067 0.0 MG
4X2
HOH
 5.742
6.786
2.694
 N
CA
O
 MG
O10
O
5bsk 1 P00492 98.62 3e-159 X-RAY
 2015-09-23 GLY A:70 A:69 17.0 0.227 S 108.2 117.9 17.0 0.227 0.0 4X7
MG
HOH
 5.007
2.488
2.865
 O
O
O
 OAD
MG
O
GLY B:70 B:69 18.0 0.24 S 74.2 148.8 17.0 0.227 0.013 D:P00492:0.013
 4X7
MG
HOH
 6.440
3.393
2.261
 CA
O
O
 OAD
MG
O
GLY C:70 C:69 12.0 0.16 S 88.1 147.5 12.0 0.16 0.0 4X7
MG
HOH
 6.252
3.738
3.642
 CA
O
O
 OAD
MG
O
GLY D:70 D:69 6.0 0.08 S 91.5 168.9 4.0 0.053 0.027 B:P00492:0.027
 4X7
MG
HOH
 5.707
5.187
3.166
 CA
O
O
 OAD
MG
O
5w8v 1 P00492 100.0 7e-159 X-RAY
 2017-08-30 GLY A:67 A:69 4.0 0.053 T -60.7 -22.7 4.0 0.053 0.0 9YP
MG
HOH
 5.621
5.303
2.441
 N
CA
O
 OAE
MG
O
GLY B:67 B:69 5.0 0.067 T -57.5 -20.4 5.0 0.067 0.0 9YP
MG
HOH
 5.994
5.449
2.637
 N
CA
O
 OAE
MG
O
GLY C:67 C:69 5.0 0.067 T -56.7 -22.1 5.0 0.067 0.0 9YP
MG
HOH
 5.355
5.548
2.770
 N
CA
O
 OAC
MG
O
GLY D:67 D:69 5.0 0.067 T -57.6 -25.2 5.0 0.067 0.0 9YP
MG
HOH
 6.054
5.341
2.629
 N
CA
O
 OAC
MG
O
1d6n 1 P00492 99.07 6e-157 X-RAY
 1999-12-30 GLY A:66 A:69 28.0 0.373 S 97.5 -30.3 10.0 0.133 0.24 B:P00492:0.24
 MG
PPO
PRP
HOH
 7.896
9.174
3.323
4.939
 N
CA
N
N
 MG
N3
O3B
O
GLY B:66 B:69 23.0 0.307 S 125.4 68.2 17.0 0.227 0.08 A:P00492:0.08
 MG
PPO
PRP
HOH
 6.280
7.414
2.594
4.995
 O
O
O
C
 MG
N1
O2B
O
2vfa 1 P20035,P00492 80.48 3e-122 X-RAY
 2008-06-17 GLY A:78 A:78 45.0 0.6 S 88.4 39.6 45.0 0.6 0.0 5GP
HOH
 6.777
5.434
 N
N
 O2'
O
GLY B:78 B:78 40.0 0.533 S 75.7 -122.8 40.0 0.533 0.0 5GP
HOH
 5.555
3.575
 N
N
 O3'
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00492-f1 1 P00492 100.0 2e-162 GLY A:70 A:70 7.0 0.093 T -55.6 -33.1