Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chrX 133609298 . C A CCDS14641.1:NM_000194.2:c.222ttC>ttA_NP_000185.1:p.74F>L Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1bzy 1 P00492 100.0 3e-161 X-RAY
 1999-06-22 PHE A:73 A:73 3.0 0.014 H -64.0 -40.9 3.0 0.014 0.0 HOH
 2.979
 N
 O
PHE B:73 B:73 1.0 0.005 H -60.5 -37.8 1.0 0.005 0.0 HOH
 3.106
 N
 O
PHE C:73 C:73 0.0 0.0 H -60.6 -36.3 0.0 0.0 0.0 HOH
 3.137
 N
 O
PHE D:73 D:73 2.0 0.01 H -60.5 -38.7 2.0 0.01 0.0 HOH
 2.926
 N
 O
1hmp 1 P00492 100.0 3e-161 X-RAY
 1995-06-03 PHE A:73 A:73 3.0 0.014 H -62.3 -46.9 3.0 0.014 0.0 5GP
HOH
 9.961
2.903
 CD2
N
 O3'
O
PHE B:73 B:73 1.0 0.005 H -70.4 -38.6 1.0 0.005 0.0 HOH
 7.720
 N
 O
1z7g 1 P00492 100.0 3e-161 X-RAY
 2005-08-02 PHE A:73 A:73 0.0 0.0 H -58.7 -43.9 0.0 0.0 0.0 HOH
 3.125
 N
 O
PHE B:73 B:73 0.0 0.0 H -60.7 -44.6 0.0 0.0 0.0 HOH
 3.167
 N
 O
PHE C:73 C:73 0.0 0.0 H -66.0 -43.5 NA NA NA
PHE D:73 D:73 0.0 0.0 H -63.0 -44.2 NA NA NA
3gep 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 PHE A:73 A:73 2.0 0.01 H -68.6 -45.5 2.0 0.01 0.0 HOH
 3.363
 N
 O
PHE B:73 B:73 0.0 0.0 H -61.5 -37.5 0.0 0.0 0.0 HOH
 2.956
 N
 O
3ggc 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 PHE A:73 A:73 4.0 0.019 H -53.1 -51.9 4.0 0.019 0.0 HOH
 3.865
 N
 O
PHE B:73 B:73 0.0 0.0 H -63.3 -38.5 0.0 0.0 0.0 HOH
 7.826
 N
 O
3ggj 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 PHE A:73 A:73 4.0 0.019 H -57.0 -45.4 4.0 0.019 0.0 HOH
 4.129
 N
 O
PHE B:73 B:73 0.0 0.0 H -65.3 -42.7 0.0 0.0 0.0 HOH
 6.057
 CD2
 O
4rab 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 PHE A:73 A:73 1.0 0.005 H -57.3 -42.4 1.0 0.005 0.0 MG
HOH
 9.042
2.885
 CD2
N
 MG
O
PHE B:73 B:73 1.0 0.005 H -57.5 -36.3 1.0 0.005 0.0 MG
HOH
 9.235
2.788
 CD2
N
 MG
O
PHE C:73 C:73 2.0 0.01 H -58.9 -43.6 2.0 0.01 0.0 MG
HOH
 9.564
2.762
 CD2
N
 MG
O
PHE D:73 D:73 1.0 0.005 H -58.4 -38.7 1.0 0.005 0.0 MG
HOH
 9.436
2.945
 CD2
N
 MG
O
4rac 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 PHE A:73 A:73 1.0 0.005 H -61.6 -41.0 1.0 0.005 0.0 MG
HOH
 9.120
2.876
 CD2
N
 MG
O
PHE B:73 B:73 1.0 0.005 H -61.4 -42.2 1.0 0.005 0.0 MG
HOH
 9.058
2.866
 CD2
N
 MG
O
PHE C:73 C:73 1.0 0.005 H -52.0 -44.3 1.0 0.005 0.0 MG
HOH
 9.233
2.957
 CD2
N
 MG
O
PHE D:73 D:73 1.0 0.005 H -55.3 -46.4 1.0 0.005 0.0 MG
HOH
 9.494
2.698
 CD2
N
 MG
O
4rad 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 PHE A:73 A:73 1.0 0.005 H -57.9 -41.2 1.0 0.005 0.0 MG
HOH
 8.745
2.031
 HD2
H
 MG
O
PHE B:73 B:73 1.0 0.005 H -55.8 -41.4 1.0 0.005 0.0 MG
HOH
 9.077
2.230
 HD2
H
 MG
O
PHE C:73 C:73 2.0 0.01 H -57.6 -43.6 2.0 0.01 0.0 3L5
MG
HOH
 9.477
8.702
2.079
 HB2
HD2
H
 OAF
MG
O
PHE D:73 D:73 0.0 0.0 H -59.2 -42.1 0.0 0.0 0.0 3L5
MG
HOH
 8.938
8.777
2.083
 HB3
HD2
H
 H6
MG
O
PHE E:73 E:73 1.0 0.005 H -57.3 -41.8 NA NA NA
PHE F:73 F:73 1.0 0.005 H -56.9 -41.4 NA NA NA
PHE G:73 G:73 1.0 0.005 H -55.7 -44.7 NA NA NA
PHE H:73 H:73 1.0 0.005 H -59.3 -41.6 NA NA NA
4ran 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 PHE A:73 A:73 1.0 0.005 H -62.5 -38.4 1.0 0.005 0.0 MG
HOH
 9.946
7.054
 CD2
N
 MG
O
PHE B:73 B:73 1.0 0.005 H -62.0 -44.5 1.0 0.005 0.0 MG
HOH
 9.910
8.776
 CD2
CZ
 MG
O
PHE C:73 C:73 1.0 0.005 H -61.6 -44.3 1.0 0.005 0.0 MG
HOH
 9.829
9.942
 CD2
CB
 MG
O
PHE D:73 D:73 1.0 0.005 H -67.5 -35.6 1.0 0.005 0.0 MG
 9.774
 CD2
 MG
4rao 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 PHE A:73 A:73 2.0 0.01 H -54.8 -42.9 2.0 0.01 0.0 MG
HOH
 9.532
2.936
 CD2
N
 MG
O
PHE B:73 B:73 1.0 0.005 H -56.5 -41.3 1.0 0.005 0.0 MG
HOH
 9.175
2.827
 CD2
N
 MG
O
PHE C:73 C:73 1.0 0.005 H -52.5 -44.6 1.0 0.005 0.0 MG
HOH
 9.423
2.820
 CD2
N
 MG
O
PHE D:73 D:73 1.0 0.005 H -59.8 -40.1 1.0 0.005 0.0 MG
HOH
 9.500
2.778
 CD2
N
 MG
O
4raq 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 PHE A:73 A:73 1.0 0.005 H -52.7 -48.5 1.0 0.005 0.0 MG
HOH
 9.676
3.051
 CB
N
 MG
O
PHE B:73 B:73 2.0 0.01 H -63.5 -45.4 2.0 0.01 0.0 MG
HOH
 9.774
6.852
 CB
O
 MG
O
PHE C:73 C:73 1.0 0.005 H -54.9 -41.0 1.0 0.005 0.0 MG
HOH
 9.650
7.139
 CD2
O
 MG
O
PHE D:73 D:73 1.0 0.005 H -52.6 -49.4 1.0 0.005 0.0 MG
HOH
 9.775
2.882
 CB
N
 MG
O
4ijq 1 P00492 100.0 4e-161 X-RAY
 2013-03-27 PHE A:79 A:73 1.0 0.005 H -57.6 -39.0 1.0 0.005 0.0 MG
HOH
 9.175
2.901
 CD2
N
 MG
O
PHE B:79 B:73 2.0 0.01 H -56.0 -42.9 2.0 0.01 0.0 MG
HOH
 9.217
2.839
 CD2
N
 MG
O
PHE C:79 C:73 1.0 0.005 H -52.5 -41.4 1.0 0.005 0.0 MG
HOH
 9.178
2.794
 CD2
N
 MG
O
PHE D:79 D:73 2.0 0.01 H -59.7 -43.4 2.0 0.01 0.0 MG
HOH
 9.386
2.862
 CD2
N
 MG
O
4kn6 1 P00492 100.0 1e-160 X-RAY
 2013-08-14 PHE A:72 A:73 5.0 0.024 H -58.0 -59.3 5.0 0.024 0.0 1RP
HOH
 9.665
2.110
 HD2
H
 O2'
O
6bnj 1 P00492 99.08 6e-160 X-RAY
 2017-12-06 PHE A:74 A:73 2.0 0.01 H -53.1 -45.6 2.0 0.01 0.0 MG
HOH
 9.372
2.824
 CD2
N
 MG
O
PHE B:74 B:73 2.0 0.01 H -52.7 -45.5 2.0 0.01 0.0 MG
HOH
 9.571
2.778
 CD2
N
 MG
O
PHE C:74 C:73 1.0 0.005 H -53.4 -44.3 1.0 0.005 0.0 MG
HOH
 9.190
2.811
 CD2
N
 MG
O
PHE D:74 D:73 1.0 0.005 H -58.7 -43.4 1.0 0.005 0.0 MG
HOH
 9.199
2.696
 CD2
N
 MG
O
5hia 1 P00492 99.08 8e-160 X-RAY
 2017-01-18 PHE A:80 A:73 2.0 0.01 H -55.3 -42.7 2.0 0.01 0.0 MG
HOH
 9.256
2.953
 CD2
N
 MG
O
PHE B:80 B:73 1.0 0.005 H -58.7 -42.5 1.0 0.005 0.0 MG
HOH
 9.198
3.031
 CD2
N
 MG
O
PHE C:80 C:73 1.0 0.005 H -54.1 -44.7 1.0 0.005 0.0 MG
HOH
 9.208
2.873
 CD2
N
 MG
O
PHE D:80 D:73 2.0 0.01 H -54.1 -43.3 2.0 0.01 0.0 MG
HOH
 9.266
2.876
 CD2
N
 MG
O
5brn 1 P00492 98.62 3e-159 X-RAY
 2015-10-14 PHE A:74 A:73 1.0 0.005 H -57.1 -39.8 1.0 0.005 0.0 MG
HOH
 9.674
3.036
 CD2
N
 MG
O
PHE B:74 B:73 0.0 0.0 H -66.2 -37.1 0.0 0.0 0.0 MG
HOH
 9.235
3.108
 CD2
N
 MG
O
PHE C:74 C:73 2.0 0.01 H -63.5 -37.4 2.0 0.01 0.0 MG
HOH
 9.656
2.979
 CD2
N
 MG
O
PHE D:74 D:73 1.0 0.005 H -52.8 -43.8 1.0 0.005 0.0 MG
HOH
 9.546
2.745
 CD2
N
 MG
O
5bsk 1 P00492 98.62 3e-159 X-RAY
 2015-09-23 PHE A:74 A:73 0.0 0.0 H -71.9 -34.7 0.0 0.0 0.0 MG
HOH
 8.268
6.974
 CD2
N
 MG
O
PHE B:74 B:73 0.0 0.0 H -67.7 -34.3 0.0 0.0 0.0 MG
HOH
 8.633
5.223
 CD2
N
 MG
O
PHE C:74 C:73 0.0 0.0 H -66.5 -35.8 0.0 0.0 0.0 MG
HOH
 8.693
9.146
 CD2
CB
 MG
O
PHE D:74 D:73 0.0 0.0 H -70.8 -38.0 0.0 0.0 0.0 MG
HOH
 9.095
7.323
 CD2
N
 MG
O
5w8v 1 P00492 100.0 7e-159 X-RAY
 2017-08-30 PHE A:71 A:73 0.0 0.0 H -65.4 -33.3 0.0 0.0 0.0 MG
HOH
 9.483
2.923
 CD2
N
 MG
O
PHE B:71 B:73 1.0 0.005 H -59.1 -40.4 1.0 0.005 0.0 MG
HOH
 9.468
2.964
 CD2
N
 MG
O
PHE C:71 C:73 2.0 0.01 H -59.1 -38.7 2.0 0.01 0.0 MG
HOH
 9.653
2.829
 CD2
N
 MG
O
PHE D:71 D:73 2.0 0.01 H -62.2 -36.4 2.0 0.01 0.0 MG
HOH
 9.472
2.857
 CD2
N
 MG
O
1d6n 1 P00492 99.07 6e-157 X-RAY
 1999-12-30 PHE A:70 A:73 2.0 0.01 H -22.7 -54.0 2.0 0.01 0.0 MG
PRP
HOH
 7.693
8.323
6.261
 CD2
CB
CD2
 MG
O2B
O
PHE B:70 B:73 0.0 0.0 H -40.0 -28.9 0.0 0.0 0.0 MG
PRP
HOH
 9.092
8.497
6.906
 CD2
CB
N
 MG
O2B
O
2vfa 1 P20035,P00492 80.48 3e-122 X-RAY
 2008-06-17 PHE A:82 A:82 0.0 0.0 H -60.8 -45.3 0.0 0.0 0.0 HOH
 5.613
 N
 O
PHE B:82 B:82 0.0 0.0 H -61.9 -45.0 0.0 0.0 0.0 HOH
 6.592
 N
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00492-f1 1 P00492 100.0 2e-162 PHE A:74 A:74 1.0 0.005 H -58.6 -42.5