Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chrX | 133624229 | . | T | A | CCDS14641.1:NM_000194.2:c.396atT>atA_NP_000185.1:p.132I>I | Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1bzy | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
1999-06-22 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -85.8 | 131.1 | 0.0 | 0.0 | 0.0 |
IMU HOH |
9.494 7.452 |
CG2 CD1 |
O3' O |
||
| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -90.9 | 129.6 | 0.0 | 0.0 | 0.0 |
IMU HOH |
9.412 7.453 |
CG2 CD1 |
O3' O |
|||||||||
| ILE | C:131 | C:131 | 0.0 | 0.0 | E | -86.7 | 133.0 | 0.0 | 0.0 | 0.0 |
IMU HOH |
9.546 7.941 |
CG2 CG2 |
O3' O |
|||||||||
| ILE | D:131 | D:131 | 0.0 | 0.0 | E | -84.9 | 131.8 | 0.0 | 0.0 | 0.0 |
IMU HOH |
9.328 6.451 |
CG2 CD1 |
O3' O |
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| 1hmp | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
1995-06-03 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -98.9 | 126.2 | 0.0 | 0.0 | 0.0 |
HOH |
7.579 |
C |
O |
||
| ILE | B:131 | B:131 | 1.0 | 0.006 | E | -101.4 | 139.3 | 1.0 | 0.006 | 0.0 |
HOH |
7.753 |
CD1 |
O |
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| 1z7g | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2005-08-02 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -91.3 | 130.2 | 0.0 | 0.0 | 0.0 |
HOH |
7.264 |
CG2 |
O |
||
| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -84.9 | 129.5 | 0.0 | 0.0 | 0.0 |
HOH |
8.116 |
CG2 |
O |
|||||||||
| ILE | C:131 | C:131 | 0.0 | 0.0 | E | -88.7 | 126.3 | NA | NA | NA | |||||||||||||
| ILE | D:131 | D:131 | 0.0 | 0.0 | E | -87.9 | 125.7 | NA | NA | NA | |||||||||||||
| 3gep | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2009-08-18 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -89.7 | 127.2 | 0.0 | 0.0 | 0.0 |
HOH |
7.098 |
C |
O |
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| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -84.5 | 123.4 | 0.0 | 0.0 | 0.0 |
HOH |
6.111 |
C |
O |
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| 3ggc | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2009-08-18 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -95.0 | 124.3 | 0.0 | 0.0 | 0.0 |
HOH |
6.616 |
C |
O |
||
| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -92.5 | 125.0 | 0.0 | 0.0 | 0.0 |
HOH |
7.912 |
CG1 |
O |
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| 3ggj | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2009-08-18 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -95.8 | 124.0 | 0.0 | 0.0 | 0.0 |
HOH |
6.626 |
C |
O |
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| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -89.2 | 122.2 | 0.0 | 0.0 | 0.0 |
HOH |
6.394 |
C |
O |
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| 4rab | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2015-01-07 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -88.3 | 127.0 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.297 7.192 |
CG2 CG2 |
MG O |
||
| ILE | B:131 | B:131 | 2.0 | 0.011 | E | -89.9 | 129.3 | 2.0 | 0.011 | 0.0 |
MG HOH |
8.410 7.048 |
CG2 CG2 |
MG O |
|||||||||
| ILE | C:131 | C:131 | 0.0 | 0.0 | E | -95.3 | 131.9 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.882 8.551 |
CG2 CG2 |
MG O |
|||||||||
| ILE | D:131 | D:131 | 0.0 | 0.0 | E | -94.9 | 126.3 | 0.0 | 0.0 | 0.0 |
MG HOH |
9.154 8.765 |
CG2 CG2 |
MG O |
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| 4rac | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2015-01-07 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -84.5 | 136.7 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.699 7.219 |
CG2 CG2 |
MG O |
||
| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -83.7 | 128.1 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.445 8.230 |
CG2 CG2 |
MG O |
|||||||||
| ILE | C:131 | C:131 | 0.0 | 0.0 | E | -85.2 | 133.0 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.459 7.323 |
CG2 CG2 |
MG O |
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| ILE | D:131 | D:131 | 0.0 | 0.0 | E | -93.0 | 126.0 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.956 8.952 |
CG2 CG2 |
MG O |
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| 4rad | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2015-01-07 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -83.0 | 125.3 | 0.0 | 0.0 | 0.0 |
3L5 MG HOH |
9.746 6.734 7.814 |
HG22 HG22 HG21 |
H15 MG O |
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| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -85.8 | 125.9 | 0.0 | 0.0 | 0.0 |
3L5 MG HOH |
9.770 6.987 6.647 |
HG22 HG22 HG22 |
H9 MG O |
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| ILE | C:131 | C:131 | 0.0 | 0.0 | E | -90.7 | 125.0 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.024 6.496 |
HG22 HD12 |
MG O |
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| ILE | D:131 | D:131 | 0.0 | 0.0 | E | -87.1 | 127.6 | 0.0 | 0.0 | 0.0 |
3L5 MG HOH |
9.829 8.457 6.310 |
HG22 HG22 HD12 |
H15 MG O |
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| ILE | E:131 | E:131 | 0.0 | 0.0 | E | -88.8 | 124.6 | NA | NA | NA | |||||||||||||
| ILE | F:131 | F:131 | 0.0 | 0.0 | E | -83.6 | 123.9 | NA | NA | NA | |||||||||||||
| ILE | G:131 | G:131 | 4.0 | 0.023 | E | -86.6 | 127.0 | NA | NA | NA | |||||||||||||
| ILE | H:131 | H:131 | 0.0 | 0.0 | E | -85.1 | 124.6 | NA | NA | NA | |||||||||||||
| 4ran | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2015-01-07 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -83.4 | 134.1 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.510 8.846 |
CG2 CG2 |
MG O |
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| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -86.3 | 127.7 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.863 7.363 |
CG2 CD1 |
MG O |
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| ILE | C:131 | C:131 | 0.0 | 0.0 | E | -94.0 | 126.3 | 0.0 | 0.0 | 0.0 |
MG |
8.602 |
CG2 |
MG |
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| ILE | D:131 | D:131 | 0.0 | 0.0 | E | -87.3 | 126.4 | 0.0 | 0.0 | 0.0 |
MG |
9.189 |
CG2 |
MG |
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| 4rao | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2015-01-07 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -85.7 | 128.8 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.651 7.303 |
CG2 CD1 |
MG O |
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| ILE | B:131 | B:131 | 3.0 | 0.017 | E | -84.3 | 127.6 | 3.0 | 0.017 | 0.0 |
3L7 MG HOH |
9.682 8.454 8.559 |
CG2 CG2 CG2 |
CAJ MG O |
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| ILE | C:131 | C:131 | 0.0 | 0.0 | E | -91.1 | 129.4 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.711 7.665 |
CG2 CG2 |
MG O |
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| ILE | D:131 | D:131 | 0.0 | 0.0 | E | -90.3 | 129.0 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.668 7.387 |
CG2 CD1 |
MG O |
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| 4raq | 1 | P00492 | 100.0 | 3e-161 |
X-RAY |
2015-01-07 | ILE | A:131 | A:131 | 0.0 | 0.0 | E | -71.9 | 128.6 | 0.0 | 0.0 | 0.0 |
MG HOH |
9.420 7.569 |
CG2 CD1 |
MG O |
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| ILE | B:131 | B:131 | 0.0 | 0.0 | E | -76.6 | 132.4 | 0.0 | 0.0 | 0.0 |
MG HOH |
9.831 8.680 |
CG2 CG2 |
MG O |
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| ILE | C:131 | C:131 | 0.0 | 0.0 | E | -80.6 | 123.5 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.002 8.633 |
CG2 CG2 |
MG O |
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| ILE | D:131 | D:131 | 0.0 | 0.0 | E | -88.2 | 131.3 | 0.0 | 0.0 | 0.0 |
MG HOH |
9.625 7.171 |
CG2 CD1 |
MG O |
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| 4ijq | 1 | P00492 | 100.0 | 4e-161 |
X-RAY |
2013-03-27 | ILE | A:137 | A:131 | 0.0 | 0.0 | E | -88.4 | 130.9 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.766 7.412 |
CG2 CD1 |
MG O |
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| ILE | B:137 | B:131 | 0.0 | 0.0 | E | -89.3 | 131.9 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.643 7.785 |
CG2 CD1 |
MG O |
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| ILE | C:137 | C:131 | 0.0 | 0.0 | E | -94.7 | 128.0 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.707 7.731 |
CG2 CD1 |
MG O |
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| ILE | D:137 | D:131 | 0.0 | 0.0 | E | -95.4 | 129.5 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.743 8.595 |
CG2 CG2 |
MG O |
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| 4kn6 | 1 | P00492 | 100.0 | 1e-160 |
X-RAY |
2013-08-14 | ILE | A:130 | A:131 | 0.0 | 0.0 | E | -79.6 | 128.2 | 0.0 | 0.0 | 0.0 |
HOH |
7.108 |
HG22 |
O |
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| 6bnj | 1 | P00492 | 99.08 | 6e-160 |
X-RAY |
2017-12-06 | ILE | A:132 | A:131 | 0.0 | 0.0 | E | -90.0 | 131.6 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.741 7.390 |
CG2 CD1 |
MG O |
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| ILE | B:132 | B:131 | 0.0 | 0.0 | E | -88.8 | 131.5 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.527 6.320 |
CG2 CD1 |
MG O |
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| ILE | C:132 | C:131 | 0.0 | 0.0 | E | -94.5 | 129.5 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.710 7.261 |
CG2 CD1 |
MG O |
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| ILE | D:132 | D:131 | 0.0 | 0.0 | E | -89.1 | 128.7 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.854 7.543 |
CG2 CG2 |
MG O |
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| 5hia | 1 | P00492 | 99.08 | 8e-160 |
X-RAY |
2017-01-18 | ILE | A:138 | A:131 | 0.0 | 0.0 | E | -85.6 | 129.0 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.826 7.343 |
CG2 CD1 |
MG O |
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| ILE | B:138 | B:131 | 0.0 | 0.0 | E | -90.5 | 132.7 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.789 7.151 |
CG2 CD1 |
MG O |
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| ILE | C:138 | C:131 | 0.0 | 0.0 | E | -90.6 | 129.2 | 0.0 | 0.0 | 0.0 |
YPG MG HOH |
9.988 8.780 7.184 |
CG2 CG2 CD1 |
OAF MG O |
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| ILE | D:138 | D:131 | 0.0 | 0.0 | E | -87.2 | 131.6 | 0.0 | 0.0 | 0.0 |
YPG MG HOH |
9.997 8.716 7.262 |
CG2 CG2 CD1 |
OAF MG O |
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| 5brn | 1 | P00492 | 98.62 | 3e-159 |
X-RAY |
2015-10-14 | ILE | A:132 | A:131 | 0.0 | 0.0 | E | -86.7 | 121.8 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.390 7.604 |
CG2 CG2 |
MG O |
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| ILE | B:132 | B:131 | 0.0 | 0.0 | E | -89.9 | 126.4 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.549 7.828 |
CG2 CG2 |
MG O |
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| ILE | C:132 | C:131 | 0.0 | 0.0 | E | -90.1 | 125.2 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.670 7.635 |
CG2 CD1 |
MG O |
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| ILE | D:132 | D:131 | 0.0 | 0.0 | E | -90.0 | 122.9 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.613 7.613 |
CG2 CG2 |
MG O |
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| 5bsk | 1 | P00492 | 98.62 | 3e-159 |
X-RAY |
2015-09-23 | ILE | A:132 | A:131 | 0.0 | 0.0 | E | -85.4 | 123.6 | 0.0 | 0.0 | 0.0 |
MG HOH |
9.221 7.877 |
CG2 CG2 |
MG O |
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| ILE | B:132 | B:131 | 0.0 | 0.0 | E | -89.3 | 123.9 | 0.0 | 0.0 | 0.0 |
MG HOH |
9.241 8.022 |
CG2 CG2 |
MG O |
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| ILE | C:132 | C:131 | 1.0 | 0.006 | E | -90.6 | 122.6 | 1.0 | 0.006 | 0.0 |
MG HOH |
8.931 7.318 |
CG2 CD1 |
MG O |
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| ILE | D:132 | D:131 | 0.0 | 0.0 | E | -86.2 | 114.6 | 0.0 | 0.0 | 0.0 |
MG HOH |
9.341 8.643 |
CG2 CG2 |
MG O |
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| 5w8v | 1 | P00492 | 100.0 | 7e-159 |
X-RAY |
2017-08-30 | ILE | A:129 | A:131 | 0.0 | 0.0 | E | -93.7 | 128.3 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.854 6.589 |
CG2 CD1 |
MG O |
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| ILE | B:129 | B:131 | 0.0 | 0.0 | E | -89.5 | 126.3 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.697 7.394 |
CG2 CG2 |
MG O |
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| ILE | C:129 | C:131 | 0.0 | 0.0 | E | -85.9 | 125.0 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.637 7.588 |
CG2 CG2 |
MG O |
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| ILE | D:129 | D:131 | 0.0 | 0.0 | E | -89.6 | 129.7 | 0.0 | 0.0 | 0.0 |
MG HOH |
8.725 7.354 |
CG2 CG2 |
MG O |
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| 1d6n | 1 | P00492 | 99.07 | 6e-157 |
X-RAY |
1999-12-30 | ILE | A:128 | A:131 | 1.0 | 0.006 | E | -117.6 | 131.0 | 1.0 | 0.006 | 0.0 |
MG PRP HOH |
8.747 8.582 7.296 |
CG2 CG2 CG2 |
MG O3 O |
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| ILE | B:128 | B:131 | 2.0 | 0.011 | -99.3 | 173.0 | 2.0 | 0.011 | 0.0 |
MG PRP HOH |
7.879 8.789 7.897 |
CG2 CG2 CG2 |
MG O3 O |
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| 2vfa | 1 | P20035,P00492 | 80.48 | 3e-122 |
X-RAY |
2008-06-17 | ILE | A:140 | A:140 | 0.0 | 0.0 | E | -81.8 | 117.3 | 0.0 | 0.0 | 0.0 |
SO4 HOH |
9.485 7.996 |
CG2 CD1 |
O3 O |
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| ILE | B:140 | B:140 | 0.0 | 0.0 | E | -86.8 | 117.9 | 0.0 | 0.0 | 0.0 |
SO4 |
8.276 |
CG2 |
O3 |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p00492-f1 | 1 | P00492 | 100.0 | 2e-162 | ILE | A:132 | A:132 | 0.0 | 0.0 | E | -83.0 | 132.6 | |