Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chrX 133627563 . T A CCDS14641.1:NM_000194.2:c.428aTg>aAg_NP_000185.1:p.143M>K Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1bzy 1 P00492 100.0 3e-161 X-RAY
 1999-06-22 MET A:142 A:142 1.0 0.005 H -66.4 -30.5 1.0 0.005 0.0 MG
IMU
POP
HOH
 8.556
4.920
8.621
2.724
 CE
N
N
N
 MG
O2P
O5
O
MET B:142 B:142 1.0 0.005 H -62.5 -38.0 1.0 0.005 0.0 MG
IMU
POP
HOH
 8.264
4.752
8.516
3.052
 CE
N
N
N
 MG
O2P
O5
O
MET C:142 C:142 3.0 0.016 H -55.4 -41.4 3.0 0.016 0.0 MG
IMU
POP
HOH
 8.239
5.013
8.592
3.142
 CE
N
N
N
 MG
O2P
O5
O
MET D:142 D:142 1.0 0.005 H -63.8 -35.3 1.0 0.005 0.0 MG
IMU
POP
HOH
 8.243
5.120
8.608
3.078
 CE
N
N
N
 MG
O3P
O5
O
1hmp 1 P00492 100.0 3e-161 X-RAY
 1995-06-03 MET A:142 A:142 1.0 0.005 H -56.6 -48.3 1.0 0.005 0.0 5GP
HOH
 4.879
2.481
 N
N
 O3P
O
MET B:142 B:142 1.0 0.005 H -71.1 -46.9 1.0 0.005 0.0 5GP
HOH
 5.226
6.676
 N
N
 O1P
O
1z7g 1 P00492 100.0 3e-161 X-RAY
 2005-08-02 MET A:142 A:142 0.0 0.0 H -74.8 -40.7 0.0 0.0 0.0 HOH
 4.774
 N
 O
MET B:142 B:142 0.0 0.0 H -67.0 -38.1 0.0 0.0 0.0 HOH
 5.210
 O
 O
MET C:142 C:142 6.0 0.032 H -62.8 -47.7 NA NA NA
MET D:142 D:142 0.0 0.0 H -63.2 -41.7 NA NA NA
3gep 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 MET A:142 A:142 2.0 0.011 H -66.2 -43.3 2.0 0.011 0.0 24H
HOH
 4.874
3.020
 N
N
 OAC
O
MET B:142 B:142 12.0 0.065 H -56.4 -50.2 12.0 0.065 0.0 24H
HOH
 5.036
2.982
 N
N
 OAF
O
3ggc 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 MET A:142 A:142 3.0 0.016 H -62.2 -52.9 3.0 0.016 0.0 H26
HOH
 4.792
2.742
 N
N
 OAE
O
MET B:142 B:142 12.0 0.065 H -67.0 -47.6 12.0 0.065 0.0 H26
HOH
 5.016
2.498
 N
N
 OAE
O
3ggj 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 MET A:142 A:142 2.0 0.011 H -65.3 -46.8 2.0 0.011 0.0 25H
HOH
 4.765
2.732
 N
N
 OAE
O
MET B:142 B:142 13.0 0.07 H -59.3 -45.8 13.0 0.07 0.0 25H
HOH
 4.959
2.913
 N
N
 OAE
O
4rab 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 MET A:142 A:142 2.0 0.011 H -68.8 -41.9 2.0 0.011 0.0 3L3
MG
HOH
 4.775
5.949
3.067
 N
CE
N
 OAF
MG
O
MET B:142 B:142 7.0 0.038 H -88.2 -34.6 7.0 0.038 0.0 3L3
MG
HOH
 4.827
7.725
3.142
 N
CB
N
 OAF
MG
O
MET C:142 C:142 1.0 0.005 H -71.4 -40.1 1.0 0.005 0.0 3L3
MG
HOH
 4.910
7.176
3.016
 N
SD
N
 OAE
MG
O
MET D:142 D:142 2.0 0.011 H -74.1 -41.5 2.0 0.011 0.0 3L3
HOH
 4.869
3.096
 N
N
 OAE
O
4rac 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 MET A:142 A:142 3.0 0.016 H -59.6 -47.9 3.0 0.016 0.0 3L4
MG
HOH
 4.786
7.331
2.968
 N
CE
N
 OAE
MG
O
MET B:142 B:142 1.0 0.005 H -70.1 -33.3 1.0 0.005 0.0 3L4
MG
HOH
 4.833
6.868
3.002
 N
CE
N
 OAE
MG
O
MET C:142 C:142 1.0 0.005 H -73.4 -25.9 1.0 0.005 0.0 3L4
MG
HOH
 4.650
7.141
3.002
 N
CE
N
 OAC
MG
O
MET D:142 D:142 1.0 0.005 H -61.2 -41.8 1.0 0.005 0.0 3L4
MG
HOH
 5.402
7.150
6.328
 N
CE
CE
 OAF
MG
O
4rad 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 MET A:142 A:142 20.0 0.108 H -56.2 -44.1 20.0 0.108 0.0 3L5
MG
HOH
 4.286
4.664
2.105
 H
H
H
 OAG
MG
O
MET B:142 B:142 1.0 0.005 H -62.1 -38.7 1.0 0.005 0.0 3L5
MG
HOH
 4.187
4.493
2.119
 H
H
H
 OAG
MG
O
MET C:142 C:142 1.0 0.005 H -72.0 -31.4 1.0 0.005 0.0 3L5
MG
HOH
 4.300
5.996
2.068
 H
HE2
H
 OAG
MG
O
MET D:142 D:142 0.0 0.0 H -79.9 -35.4 0.0 0.0 0.0 3L5
MG
HOH
 4.329
6.465
2.075
 H
HE1
H
 OAH
MG
O
MET E:142 E:142 4.0 0.022 H -66.5 -41.5 NA NA NA
MET F:142 F:142 7.0 0.038 H -61.5 -40.8 NA NA NA
MET G:142 G:142 15.0 0.081 H -58.8 -41.0 NA NA NA
MET H:142 H:142 0.0 0.0 H -82.0 -28.8 NA NA NA
4ran 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 MET A:142 A:142 1.0 0.005 H -72.9 -40.0 1.0 0.005 0.0 3L6
MG
HOH
 4.887
6.305
3.328
 N
CE
N
 OAF
MG
O
MET B:142 B:142 1.0 0.005 H -76.3 -34.9 1.0 0.005 0.0 3L6
MG
HOH
 4.965
6.715
5.901
 N
CE
CG
 OAD
MG
O
MET C:142 C:142 1.0 0.005 H -81.0 -40.4 1.0 0.005 0.0 3L6
MG
HOH
 4.593
6.061
7.975
 N
CE
CE
 OAD
MG
O
MET D:142 D:142 1.0 0.005 H -70.2 -34.1 1.0 0.005 0.0 3L6
MG
 4.907
7.010
 N
CE
 OAD
MG
4rao 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 MET A:142 A:142 2.0 0.011 H -66.0 -43.5 2.0 0.011 0.0 3L7
MG
HOH
 4.660
6.648
2.884
 N
CE
N
 OAG
MG
O
MET B:142 B:142 10.0 0.054 H -69.1 -45.0 10.0 0.054 0.0 3L7
MG
HOH
 4.728
7.401
2.996
 N
N
N
 OAG
MG
O
MET C:142 C:142 0.0 0.0 H -69.8 -38.9 0.0 0.0 0.0 3L7
MG
HOH
 4.838
6.974
2.802
 N
CE
N
 OAG
MG
O
MET D:142 D:142 1.0 0.005 H -71.7 -40.7 1.0 0.005 0.0 3L7
HOH
 4.887
2.943
 N
N
 OAF
O
4raq 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 MET A:142 A:142 1.0 0.005 H -79.7 -33.9 1.0 0.005 0.0 3L8
MG
HOH
 4.812
7.137
5.995
 N
CE
CE
 OAD
MG
O
MET B:142 B:142 2.0 0.011 H -67.3 -33.3 2.0 0.011 0.0 3L8
MG
HOH
 4.703
7.766
2.855
 N
CE
N
 OAD
MG
O
MET C:142 C:142 7.0 0.038 H -68.7 -38.6 7.0 0.038 0.0 3L8
MG
HOH
 4.933
6.703
3.376
 N
N
N
 OAD
MG
O
MET D:142 D:142 3.0 0.016 H -69.7 -45.5 3.0 0.016 0.0 3L8
MG
HOH
 5.025
7.352
2.877
 N
CE
N
 OAE
MG
O
4ijq 1 P00492 100.0 4e-161 X-RAY
 2013-03-27 MET A:148 A:142 3.0 0.016 H -63.9 -42.9 3.0 0.016 0.0 SV2
MG
HOH
 4.867
6.775
2.868
 N
CE
N
 OAH
MG
O
MET B:148 B:142 2.0 0.011 H -62.2 -38.2 2.0 0.011 0.0 SV2
MG
HOH
 4.848
6.657
2.982
 N
CE
N
 OAH
MG
O
MET C:148 C:142 1.0 0.005 H -64.3 -42.2 1.0 0.005 0.0 SV2
MG
HOH
 4.789
6.954
2.829
 N
CE
N
 OAH
MG
O
MET D:148 D:142 2.0 0.011 H -65.2 -47.5 2.0 0.011 0.0 SV2
MG
HOH
 4.895
6.899
2.942
 N
CE
N
 OAD
MG
O
4kn6 1 P00492 100.0 1e-160 X-RAY
 2013-08-14 MET A:141 A:142 1.0 0.005 H -73.7 -41.1 1.0 0.005 0.0 1RP
HOH
 4.330
4.209
 H
HE2
 OAG
O
6bnj 1 P00492 99.08 6e-160 X-RAY
 2017-12-06 MET A:143 A:142 3.0 0.016 H -67.0 -38.3 3.0 0.016 0.0 WPG
MG
HOH
 4.478
6.879
2.812
 N
CE
N
 OAI
MG
O
MET B:143 B:142 1.0 0.005 H -66.4 -39.1 1.0 0.005 0.0 WPG
MG
HOH
 4.642
7.265
2.861
 N
SD
N
 OAI
MG
O
MET C:143 C:142 2.0 0.011 H -63.7 -46.2 2.0 0.011 0.0 WPG
HOH
 4.750
3.059
 N
N
 OAI
O
MET D:143 D:142 1.0 0.005 H -65.9 -40.8 1.0 0.005 0.0 WPG
MG
HOH
 4.683
6.928
2.912
 N
CE
N
 OAE
MG
O
5hia 1 P00492 99.08 8e-160 X-RAY
 2017-01-18 MET A:149 A:142 3.0 0.016 H -65.6 -38.9 3.0 0.016 0.0 YPG
MG
HOH
 4.640
6.896
2.922
 N
CE
N
 OAI
MG
O
MET B:149 B:142 2.0 0.011 H -69.6 -38.8 2.0 0.011 0.0 YPG
MG
HOH
 4.743
7.467
2.829
 N
SD
N
 OAI
MG
O
MET C:149 C:142 1.0 0.005 H -70.6 -37.9 1.0 0.005 0.0 YPG
HOH
 4.692
2.976
 N
N
 OAI
O
MET D:149 D:142 2.0 0.011 H -69.0 -40.7 2.0 0.011 0.0 YPG
HOH
 4.707
2.924
 N
N
 OAI
O
5brn 1 P00492 98.62 3e-159 X-RAY
 2015-10-14 MET A:143 A:142 2.0 0.011 H -73.1 -42.2 2.0 0.011 0.0 MG
4X2
HOH
 6.600
5.121
3.155
 CE
N
N
 MG
O04
O
MET B:143 B:142 1.0 0.005 H -77.5 -35.1 1.0 0.005 0.0 MG
4X2
HOH
 6.810
5.085
3.889
 CE
N
N
 MG
O04
O
MET C:143 C:142 2.0 0.011 H -72.6 -40.8 2.0 0.011 0.0 MG
4X2
HOH
 6.557
5.174
3.002
 CE
N
N
 MG
O03
O
MET D:143 D:142 1.0 0.005 H -85.7 -34.9 1.0 0.005 0.0 MG
4X2
HOH
 6.385
4.989
3.107
 CE
N
N
 MG
O04
O
5bsk 1 P00492 98.62 3e-159 X-RAY
 2015-09-23 MET A:143 A:142 1.0 0.005 H -70.6 -31.7 1.0 0.005 0.0 4X7
MG
HOH
 5.128
7.431
4.018
 N
CE
CE
 OAC
MG
O
MET B:143 B:142 2.0 0.011 H -74.1 -39.6 2.0 0.011 0.0 4X7
MG
HOH
 4.921
7.085
3.006
 N
CE
N
 OAC
MG
O
MET C:143 C:142 2.0 0.011 H -78.2 -44.3 2.0 0.011 0.0 4X7
MG
HOH
 5.039
7.753
6.439
 N
SD
CE
 OAF
MG
O
MET D:143 D:142 1.0 0.005 H -72.8 -39.2 1.0 0.005 0.0 4X7
MG
HOH
 5.351
6.973
3.254
 N
SD
N
 OAC
MG
O
5w8v 1 P00492 100.0 7e-159 X-RAY
 2017-08-30 MET A:140 A:142 4.0 0.022 H -69.8 -41.8 4.0 0.022 0.0 9YP
MG
HOH
 5.179
7.213
3.049
 N
CE
N
 OAG
MG
O
MET B:140 B:142 2.0 0.011 H -67.2 -36.1 2.0 0.011 0.0 9YP
MG
HOH
 4.969
6.967
3.353
 N
SD
CG
 OAG
MG
O
MET C:140 C:142 3.0 0.016 H -70.5 -37.7 3.0 0.016 0.0 9YP
MG
HOH
 4.797
6.977
3.066
 N
SD
N
 OAG
MG
O
MET D:140 D:142 1.0 0.005 H -71.5 -41.1 1.0 0.005 0.0 9YP
HOH
 4.856
2.967
 N
N
 OAH
O
1d6n 1 P00492 99.07 6e-157 X-RAY
 1999-12-30 MET A:139 A:142 2.0 0.011 H -40.0 -44.9 2.0 0.011 0.0 MG
PRP
HOH
 6.648
4.911
5.808
 CE
N
CE
 MG
O3P
O
MET B:139 B:142 3.0 0.016 H -53.8 -50.8 3.0 0.016 0.0 MG
PRP
HOH
 6.487
3.853
7.270
 SD
N
N
 MG
O2P
O
2vfa 1 P20035,P00492 80.48 3e-122 X-RAY
 2008-06-17 MET A:151 A:151 0.0 NA H -69.2 -48.0 0.0 NA NA 5GP
SO4
HOH
 9.587
4.414
7.115
 N
N
CG
 C5'
O3
O
MET B:151 B:151 0.0 0.0 H -61.5 -43.7 0.0 0.0 0.0 5GP
SO4
HOH
 9.807
3.217
6.335
 CE
N
N
 C3'
O3
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00492-f1 1 P00492 100.0 2e-162 MET A:143 A:143 2.0 0.011 H -68.2 -39.2