Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chrX 133627594 . T A CCDS14641.1:NM_000194.2:c.459taT>taA_NP_000185.1:p.153Y>* Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
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PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1bzy 1 P00492 100.0 3e-161 X-RAY
 1999-06-22 TYR A:152 A:152 58.0 0.252 T -105.9 17.0 58.0 0.252 0.0 HOH
 6.221
 N
 O
TYR B:152 B:152 57.0 0.248 T -88.0 9.7 57.0 0.248 0.0 HOH
 4.548
 OH
 O
TYR C:152 C:152 39.0 0.17 T -100.5 7.9 39.0 0.17 0.0 HOH
 4.830
 CD2
 O
TYR D:152 D:152 56.0 0.243 T -97.8 11.8 56.0 0.243 0.0 HOH
 7.366
 N
 O
1hmp 1 P00492 100.0 3e-161 X-RAY
 1995-06-03 TYR A:152 A:152 41.0 0.178 T -47.1 8.3 41.0 0.178 0.0 HOH
 5.910
 C
 O
TYR B:152 B:152 20.0 0.087 T -81.7 -4.4 20.0 0.087 0.0 HOH
 6.340
 OH
 O
1z7g 1 P00492 100.0 3e-161 X-RAY
 2005-08-02 TYR A:152 A:152 73.0 0.317 T -99.1 14.8 73.0 0.317 0.0 HOH
 3.532
 O
 O
TYR B:152 B:152 103.0 0.448 T -96.1 4.7 103.0 0.448 0.0 HOH
 9.826
 N
 O
TYR C:152 C:152 77.0 0.335 T -97.8 13.3 NA NA NA
TYR D:152 D:152 95.0 0.413 T -83.8 3.1 NA NA NA
3gep 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 TYR A:152 A:152 96.0 0.417 T -91.9 8.3 96.0 0.417 0.0 HOH
 7.169
 O
 O
TYR B:152 B:152 80.0 0.348 T -101.0 10.3 80.0 0.348 0.0 HOH
 2.705
 OH
 O
3ggc 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 TYR A:152 A:152 96.0 0.417 T -83.4 17.9 96.0 0.417 0.0 HOH
 5.860
 O
 O
TYR B:152 B:152 82.0 0.357 T -106.4 18.5 82.0 0.357 0.0 HOH
 3.442
 OH
 O
3ggj 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 TYR A:152 A:152 99.0 0.43 T -92.9 13.6 99.0 0.43 0.0 HOH
 6.000
 O
 O
TYR B:152 B:152 83.0 0.361 G -103.9 21.1 83.0 0.361 0.0 HOH
 3.756
 OH
 O
4rab 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 TYR A:152 A:152 92.0 0.4 G -101.2 14.2 92.0 0.4 0.0 HOH
 4.249
 CA
 O
TYR B:152 B:152 83.0 0.361 G -102.6 4.7 83.0 0.361 0.0
TYR C:152 C:152 85.0 0.37 T -88.0 11.1 85.0 0.37 0.0
TYR D:152 D:152 82.0 0.357 G -99.8 7.5 82.0 0.357 0.0 HOH
 6.913
 O
 O
4rac 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 TYR A:152 A:152 70.0 0.304 T -102.8 9.1 70.0 0.304 0.0 HOH
 8.135
 CD2
 O
TYR B:152 B:152 76.0 0.33 G -90.5 8.1 76.0 0.33 0.0 HOH
 5.540
 N
 O
TYR C:152 C:152 44.0 0.191 T -107.0 -3.3 44.0 0.191 0.0 HOH
 9.510
 OH
 O
TYR D:152 NA:NA DO NA DO DO DO NA NA NA
4rad 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 TYR A:152 A:152 54.0 0.235 T -86.2 5.2 54.0 0.235 0.0 HOH
 6.384
 N
 O
TYR B:152 B:152 78.0 0.339 T -132.9 21.1 78.0 0.339 0.0 HOH
 6.382
 HE1
 O
TYR C:152 C:152 91.0 0.396 G -111.8 20.3 91.0 0.396 0.0 HOH
 2.753
 HH
 O
TYR D:152 D:152 89.0 0.387 T -115.4 21.0 89.0 0.387 0.0 HOH
 2.764
 OH
 O
TYR E:152 E:152 79.0 0.343 G -106.4 7.1 NA NA NA
TYR F:152 F:152 112.0 0.487 T -89.2 16.7 NA NA NA
TYR G:152 G:152 99.0 0.43 T -115.5 57.9 NA NA NA
TYR H:152 H:152 44.0 0.191 T -110.7 11.1 NA NA NA
4ran 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 TYR A:152 A:152 112.0 0.487 T -113.2 20.0 112.0 0.487 0.0
TYR B:152 B:152 83.0 0.361 T -115.0 14.1 83.0 0.361 0.0
TYR C:152 C:152 74.0 0.322 T -90.6 14.6 74.0 0.322 0.0 HOH
 7.755
 N
 O
TYR D:152 D:152 138.0 0.6 T -79.8 -7.6 138.0 0.6 0.0
4rao 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 TYR A:152 A:152 84.0 0.365 G -89.2 12.2 84.0 0.365 0.0 HOH
 6.575
 N
 O
TYR B:152 B:152 75.0 0.326 T -97.3 13.6 75.0 0.326 0.0
TYR C:152 C:152 86.0 0.374 T -108.8 11.8 86.0 0.374 0.0 HOH
 6.074
 O
 O
TYR D:152 D:152 76.0 0.33 G -99.3 9.3 76.0 0.33 0.0 HOH
 2.709
 OH
 O
4raq 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 TYR A:152 A:152 84.0 0.365 G -92.3 13.6 84.0 0.365 0.0
TYR B:152 B:152 88.0 0.383 T -95.3 15.7 88.0 0.383 0.0
TYR C:152 C:152 65.0 0.283 G -100.4 26.2 65.0 0.283 0.0 HOH
 8.419
 OH
 O
TYR D:152 D:152 81.0 0.352 G -112.3 18.1 81.0 0.352 0.0 HOH
 2.775
 OH
 O
4ijq 1 P00492 100.0 4e-161 X-RAY
 2013-03-27 TYR A:158 A:152 83.0 0.361 T -106.3 14.7 83.0 0.361 0.0 HOH
 4.533
 O
 O
TYR B:158 B:152 82.0 0.357 T -93.8 10.0 82.0 0.357 0.0 HOH
 7.004
 N
 O
TYR C:158 C:152 82.0 0.357 T -96.5 16.5 82.0 0.357 0.0 HOH
 7.161
 OH
 O
TYR D:158 D:152 81.0 0.352 G -102.2 6.4 81.0 0.352 0.0 HOH
 4.536
 OH
 O
4kn6 1 P00492 100.0 1e-160 X-RAY
 2013-08-14 TYR A:151 A:152 124.0 0.539 T -84.3 -3.3 124.0 0.539 0.0 HOH
 7.524
 CZ
 O
6bnj 1 P00492 99.08 6e-160 X-RAY
 2017-12-06 TYR A:153 A:152 71.0 0.309 T -97.4 12.8 71.0 0.309 0.0 HOH
 4.206
 C
 O
TYR B:153 B:152 76.0 0.33 G -105.0 13.9 76.0 0.33 0.0 HOH
 3.143
 OH
 O
TYR C:153 C:152 84.0 0.365 G -103.4 6.9 84.0 0.365 0.0 HOH
 2.518
 OH
 O
TYR D:153 D:152 83.0 0.361 G -105.4 8.5 83.0 0.361 0.0 HOH
 7.218
 CE1
 O
5hia 1 P00492 99.08 8e-160 X-RAY
 2017-01-18 TYR A:159 A:152 76.0 0.33 G -95.1 13.2 76.0 0.33 0.0 HOH
 5.804
 N
 O
TYR B:159 B:152 77.0 0.335 G -109.9 16.6 77.0 0.335 0.0 HOH
 4.180
 CD2
 O
TYR C:159 C:152 82.0 0.357 G -109.3 10.4 82.0 0.357 0.0 HOH
 2.716
 OH
 O
TYR D:159 D:152 92.0 0.4 G -98.7 12.9 92.0 0.4 0.0 HOH
 4.391
 O
 O
5brn 1 P00492 98.62 3e-159 X-RAY
 2015-10-14 TYR A:153 A:152 90.0 0.391 T -89.1 12.7 90.0 0.391 0.0 HOH
 3.726
 O
 O
TYR B:153 B:152 69.0 0.3 G -129.9 -3.7 69.0 0.3 0.0 HOH
 7.161
 CE2
 O
TYR C:153 C:152 113.0 0.491 S -95.2 18.4 113.0 0.491 0.0 HOH
 6.239
 CE2
 O
TYR D:153 D:152 74.0 0.322 T -82.3 6.0 74.0 0.322 0.0 HOH
 4.577
 O
 O
5bsk 1 P00492 98.62 3e-159 X-RAY
 2015-09-23 TYR A:153 A:152 104.0 0.452 S -84.0 -163.5 104.0 0.452 0.0
TYR B:153 B:152 131.0 0.57 G -78.1 -1.2 131.0 0.57 0.0 HOH
 9.415
 CE1
 O
TYR C:153 C:152 120.0 0.522 T -86.3 14.7 120.0 0.522 0.0 HOH
 6.798
 N
 O
TYR D:153 D:152 99.0 0.43 G -86.6 15.7 99.0 0.43 0.0 HOH
 5.403
 C
 O
5w8v 1 P00492 100.0 7e-159 X-RAY
 2017-08-30 TYR A:150 A:152 96.0 0.417 G -105.2 7.5 96.0 0.417 0.0 HOH
 4.131
 O
 O
TYR B:150 B:152 84.0 0.365 T -98.3 4.9 84.0 0.365 0.0 HOH
 4.298
 OH
 O
TYR C:150 C:152 83.0 0.361 T -96.9 21.0 83.0 0.361 0.0 HOH
 3.499
 OH
 O
TYR D:150 D:152 78.0 0.339 G -98.0 5.1 78.0 0.339 0.0 HOH
 3.647
 CE2
 O
1d6n 1 P00492 99.07 6e-157 X-RAY
 1999-12-30 TYR A:149 A:152 111.0 0.483 H -53.3 -14.0 111.0 0.483 0.0 HOH
 9.983
 N
 O
TYR B:149 B:152 116.0 0.504 S -62.8 -120.4 116.0 0.504 0.0 HOH
 6.864
 OH
 O
2vfa 1 P20035,P00492 80.48 3e-122 X-RAY
 2008-06-17 TYR A:161 A:161 72.0 0.313 T -108.0 14.6 72.0 0.313 0.0 HOH
 6.417
 O
 O
TYR B:161 B:161 79.0 0.343 T -107.8 14.2 79.0 0.343 0.0 HOH
 3.322
 OH
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00492-f1 1 P00492 100.0 2e-162 TYR A:153 A:153 73.0 0.317 T -92.3 13.6