Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chrX 133632687 . C A CCDS14641.1:NM_000194.2:c.582gaC>gaA_NP_000185.1:p.194D>E Homo sapiens hypoxanthine phosphoribosyltransferase 1 (HPRT1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1bzy 1 P00492 100.0 3e-161 X-RAY
 1999-06-22 ASP A:193 A:193 36.0 0.24 -110.2 176.7 36.0 0.24 0.0 MG
MG
IMU
POP
HOH
 6.393
2.139
2.774
2.727
2.885
 OD1
OD1
O
OD1
OD2
 MG
MG
N2
O3
O
ASP B:193 B:193 34.0 0.227 -115.1 171.3 34.0 0.227 0.0 MG
MG
IMU
POP
HOH
 6.332
2.184
2.846
2.788
2.696
 OD1
OD1
O
OD1
OD2
 MG
MG
N2
O3
O
ASP C:193 C:193 32.0 0.213 -110.2 179.6 32.0 0.213 0.0 MG
MG
IMU
POP
HOH
 6.530
2.166
2.611
2.962
2.615
 OD1
OD1
O
OD1
OD1
 MG
MG
N2
O3
O
ASP D:193 D:193 36.0 0.24 -117.1 176.2 36.0 0.24 0.0 MG
MG
IMU
POP
HOH
 6.519
2.270
2.773
2.679
3.067
 OD1
OD1
O
OD1
O
 MG
MG
N2
O3
O
1hmp 1 P00492 100.0 3e-161 X-RAY
 1995-06-03 ASP A:193 A:193 13.0 0.087 -113.7 165.5 13.0 0.087 0.0 5GP
HOH
 3.038
6.625
 O
O
 N2
O
ASP B:193 B:193 28.0 0.187 -128.2 178.9 28.0 0.187 0.0 5GP
HOH
 3.208
4.039
 O
O
 N2
O
1z7g 1 P00492 100.0 3e-161 X-RAY
 2005-08-02 ASP A:193 A:193 42.0 0.28 -69.0 158.4 42.0 0.28 0.0 HOH
 2.646
 OD1
 O
ASP B:193 B:193 43.0 0.287 -78.9 159.8 43.0 0.287 0.0 HOH
 2.603
 OD2
 O
ASP C:193 C:193 44.0 0.293 -74.1 159.3 NA NA NA
ASP D:193 D:193 43.0 0.287 -73.9 158.5 NA NA NA
3gep 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 ASP A:193 A:193 47.0 0.313 -97.2 155.1 47.0 0.313 0.0 24H
HOH
 4.107
2.680
 O
OD1
 N2
O
ASP B:193 B:193 46.0 0.307 -103.9 174.1 46.0 0.307 0.0 24H
HOH
 3.483
3.651
 O
OD2
 N2
O
3ggc 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 ASP A:193 A:193 48.0 0.32 -91.5 165.1 48.0 0.32 0.0 H26
HOH
 5.232
2.428
 O
O
 C2
O
ASP B:193 B:193 51.0 0.34 -88.3 178.9 51.0 0.34 0.0 H26
HOH
 4.676
3.993
 O
OD2
 C2
O
3ggj 1 P00492 100.0 3e-161 X-RAY
 2009-08-18 ASP A:193 A:193 47.0 0.313 -89.5 165.7 47.0 0.313 0.0 25H
HOH
 3.981
2.573
 O
O
 N2
O
ASP B:193 B:193 47.0 0.313 -91.8 -179.3 47.0 0.313 0.0 25H
HOH
 3.529
3.601
 O
OD2
 N2
O
4rab 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 ASP A:193 A:193 48.0 0.32 -115.4 162.5 48.0 0.32 0.0 3L3
MG
PO4
HOH
 2.707
9.095
3.040
5.339
 O
OD1
OD1
CB
 N2
MG
O2
O
ASP B:193 B:193 46.0 0.307 -118.5 158.5 46.0 0.307 0.0 3L3
MG
PO4
HOH
 2.791
8.618
3.120
5.344
 O
OD1
OD1
CB
 N2
MG
O1
O
ASP C:193 C:193 47.0 0.313 -123.4 157.5 47.0 0.313 0.0 3L3
MG
MG
PO4
HOH
 2.758
8.260
2.230
2.828
2.770
 O
OD1
OD1
OD1
OD1
 N2
MG
MG
O3
O
ASP D:193 D:193 44.0 0.293 -113.9 157.9 44.0 0.293 0.0 3L3
MG
MG
PO4
HOH
 2.747
7.715
2.135
3.184
5.415
 O
OD1
OD1
OD1
CB
 N2
MG
MG
O4
O
4rac 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 ASP A:193 A:193 41.0 0.273 -118.1 164.8 41.0 0.273 0.0 3L4
MG
MG
HOH
 2.710
2.261
7.946
2.647
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP B:193 B:193 43.0 0.287 -112.2 163.9 43.0 0.287 0.0 3L4
MG
MG
HOH
 2.735
2.122
8.099
2.381
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP C:193 C:193 43.0 0.287 -114.0 161.0 43.0 0.287 0.0 3L4
MG
MG
HOH
 2.716
8.182
2.399
2.772
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP D:193 D:193 43.0 0.287 -117.7 161.0 43.0 0.287 0.0 3L4
MG
HOH
 2.633
7.847
3.652
 OD2
OD1
OD1
 OAG
MG
O
4rad 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 ASP A:193 A:193 45.0 0.3 -112.8 166.2 45.0 0.3 0.0 3L5
HOH
 2.013
2.952
 O
H
 H24
O
ASP B:193 B:193 46.0 0.307 -114.1 163.7 46.0 0.307 0.0 3L5
MG
HOH
 2.419
2.594
2.756
 O
OD1
OD2
 H23
MG
O
ASP C:193 C:193 45.0 0.3 -116.0 166.0 45.0 0.3 0.0 3L5
MG
HOH
 2.323
8.473
3.669
 OD1
H
OD2
 H4
MG
O
ASP D:193 D:193 44.0 0.293 -116.5 165.3 44.0 0.293 0.0 3L5
MG
HOH
 1.928
7.902
2.622
 O
OD1
OD2
 H23
MG
O
ASP E:193 E:193 46.0 0.307 -113.2 167.8 NA NA NA
ASP F:193 F:193 51.0 0.34 -114.8 160.4 NA NA NA
ASP G:193 G:193 45.0 0.3 -121.3 169.7 NA NA NA
ASP H:193 H:193 51.0 0.34 -119.6 165.8 NA NA NA
4ran 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 ASP A:193 A:193 41.0 0.273 -129.4 169.6 41.0 0.273 0.0 3L6
MG
HOH
 2.717
8.326
6.315
 O
OD1
OD1
 N2
MG
O
ASP B:193 B:193 40.0 0.267 -113.8 169.5 40.0 0.267 0.0 3L6
MG
HOH
 2.795
7.761
7.714
 O
OD1
OD1
 N2
MG
O
ASP C:193 C:193 42.0 0.28 -111.7 160.3 42.0 0.28 0.0 3L6
MG
HOH
 2.644
8.323
4.658
 O
OD1
OD1
 N2
MG
O
ASP D:193 D:193 43.0 0.287 -118.8 171.1 43.0 0.287 0.0 3L6
MG
 2.574
7.490
 O
OD1
 N2
MG
4rao 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 ASP A:193 A:193 41.0 0.273 -113.8 162.6 41.0 0.273 0.0 3L7
MG
MG
HOH
 3.132
7.926
2.273
2.760
 OD1
OD1
OD1
O
 OAD
MG
MG
O
ASP B:193 B:193 44.0 0.293 -117.4 165.0 44.0 0.293 0.0 3L7
MG
MG
HOH
 2.968
8.188
2.164
2.388
 OD1
OD1
OD1
OD2
 OAE
MG
MG
O
ASP C:193 C:193 42.0 0.28 -117.3 162.5 42.0 0.28 0.0 3L7
MG
MG
HOH
 3.234
7.813
2.208
2.729
 OD1
OD1
OD1
OD2
 OAB
MG
MG
O
ASP D:193 D:193 42.0 0.28 -118.9 165.7 42.0 0.28 0.0 3L7
MG
MG
HOH
 2.976
7.871
2.179
2.798
 OD1
OD1
OD1
OD2
 OAE
MG
MG
O
4raq 1 P00492 100.0 3e-161 X-RAY
 2015-01-07 ASP A:193 A:193 45.0 0.3 -109.9 163.2 45.0 0.3 0.0 3L8
MG
MG
HOH
 2.874
2.902
7.206
2.654
 OD1
OD1
OD1
OD1
 OAG
MG
MG
O
ASP B:193 B:193 42.0 0.28 -101.5 160.7 42.0 0.28 0.0 3L8
MG
MG
HOH
 2.949
2.993
6.947
2.363
 OD1
OD1
OD1
OD1
 OAG
MG
MG
O
ASP C:193 C:193 43.0 0.287 -124.7 167.2 43.0 0.287 0.0 3L8
MG
MG
HOH
 3.078
2.738
8.936
2.555
 OD1
OD1
OD1
OD1
 OAF
MG
MG
O
ASP D:193 D:193 44.0 0.293 -122.9 163.8 44.0 0.293 0.0 3L8
MG
MG
HOH
 2.964
6.672
2.149
2.704
 OD1
OD1
OD1
OD1
 OAF
MG
MG
O
4ijq 1 P00492 100.0 4e-161 X-RAY
 2013-03-27 ASP A:199 A:193 40.0 0.267 -117.0 167.4 40.0 0.267 0.0 SV2
SO4
MG
MG
HOH
 2.974
2.925
8.022
2.055
2.486
 O
OD1
OD1
OD1
OD2
 N2
O4
MG
MG
O
ASP B:199 B:193 42.0 0.28 -121.3 169.7 42.0 0.28 0.0 SV2
MG
SO4
MG
HOH
 2.932
8.036
2.945
2.083
2.595
 O
OD1
OD1
OD1
OD1
 N2
MG
O1
MG
O
ASP C:199 C:193 43.0 0.287 -113.4 165.4 43.0 0.287 0.0 SV2
MG
MG
SO4
HOH
 2.875
8.167
2.310
3.074
3.214
 O
OD1
OD2
OD1
OD1
 N2
MG
MG
O1
O
ASP D:199 D:193 43.0 0.287 -118.3 164.7 43.0 0.287 0.0 MG
SV2
MG
SO4
HOH
 2.112
2.901
7.856
2.961
2.480
 OD1
O
OD1
OD1
OD2
 MG
N2
MG
O4
O
4kn6 1 P00492 100.0 1e-160 X-RAY
 2013-08-14 ASP A:192 A:193 44.0 0.293 -122.4 -176.4 44.0 0.293 0.0 1RP
HOH
 3.026
4.027
 O
HB3
 FAI
O
6bnj 1 P00492 99.08 6e-160 X-RAY
 2017-12-06 ASP A:194 A:193 43.0 0.287 -109.5 165.7 43.0 0.287 0.0 WPG
MG
MG
HOH
 2.715
8.094
2.036
2.840
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP B:194 B:193 40.0 0.267 -113.5 164.4 40.0 0.267 0.0 WPG
MG
MG
HOH
 2.773
8.124
2.106
2.561
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP C:194 C:193 41.0 0.273 -110.3 163.3 41.0 0.273 0.0 WPG
MG
MG
HOH
 2.730
8.121
2.008
2.614
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP D:194 D:193 40.0 0.267 -113.6 164.9 40.0 0.267 0.0 WPG
MG
MG
HOH
 2.810
8.006
2.036
2.589
 O
OD1
OD1
OD2
 N2
MG
MG
O
5hia 1 P00492 99.08 8e-160 X-RAY
 2017-01-18 ASP A:200 A:193 42.0 0.28 -110.3 163.8 42.0 0.28 0.0 YPG
MG
MG
HOH
 2.740
1.995
7.872
2.655
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP B:200 B:193 40.0 0.267 -116.7 163.3 40.0 0.267 0.0 YPG
MG
MG
HOH
 2.749
2.079
7.936
2.540
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP C:200 C:193 40.0 0.267 -120.3 161.9 40.0 0.267 0.0 YPG
MG
MG
HOH
 2.672
1.947
7.918
2.655
 O
OD1
OD1
OD2
 N2
MG
MG
O
ASP D:200 D:193 39.0 0.26 -118.1 162.7 39.0 0.26 0.0 YPG
MG
MG
HOH
 2.791
1.914
7.850
2.588
 O
OD1
OD1
OD2
 N2
MG
MG
O
5brn 1 P00492 98.62 3e-159 X-RAY
 2015-10-14 ASP A:194 A:193 49.0 0.327 -113.7 158.7 49.0 0.327 0.0 MG
4X2
HOH
 8.038
3.483
2.513
 OD1
O
OD1
 MG
C15
O
ASP B:194 B:193 44.0 0.293 -123.3 168.5 44.0 0.293 0.0 MG
4X2
HOH
 7.978
3.305
2.503
 OD1
O
OD1
 MG
C15
O
ASP C:194 C:193 40.0 0.267 -127.2 157.4 40.0 0.267 0.0 MG
4X2
HOH
 7.490
3.124
2.671
 OD1
O
OD2
 MG
C15
O
ASP D:194 D:193 46.0 0.307 -116.7 167.3 46.0 0.307 0.0 MG
4X2
HOH
 8.247
3.438
3.105
 OD1
O
OD1
 MG
C15
O
5bsk 1 P00492 98.62 3e-159 X-RAY
 2015-09-23 ASP A:194 A:193 45.0 0.3 -114.3 161.7 45.0 0.3 0.0 4X7
MG
HOH
 3.249
8.109
6.120
 O
OD1
OD1
 N2
MG
O
ASP B:194 B:193 47.0 0.313 -116.4 169.9 47.0 0.313 0.0 4X7
MG
HOH
 3.261
8.336
2.459
 O
OD1
OD1
 N2
MG
O
ASP C:194 C:193 47.0 0.313 -99.7 173.4 47.0 0.313 0.0 4X7
MG
HOH
 3.318
8.294
6.023
 O
OD1
CB
 N2
MG
O
ASP D:194 D:193 46.0 0.307 -135.5 171.1 46.0 0.307 0.0 4X7
MG
HOH
 2.968
8.451
5.652
 O
OD1
OD2
 N2
MG
O
5w8v 1 P00492 100.0 7e-159 X-RAY
 2017-08-30 ASP A:191 A:193 46.0 0.307 -123.2 163.5 46.0 0.307 0.0 9YP
MG
HOH
 2.794
7.952
2.979
 O
OD1
OD2
 NAA
MG
O
ASP B:191 B:193 45.0 0.3 -120.4 163.3 45.0 0.3 0.0 9YP
MG
HOH
 2.845
8.071
2.788
 O
OD1
OD1
 NAA
MG
O
ASP C:191 C:193 46.0 0.307 -119.7 168.1 46.0 0.307 0.0 9YP
MG
HOH
 2.853
8.474
2.706
 O
OD1
OD1
 NAA
MG
O
ASP D:191 D:193 50.0 0.333 -119.8 157.6 50.0 0.333 0.0 9YP
MG
HOH
 2.858
7.982
2.277
 O
OD1
OD1
 NAA
MG
O
1d6n 1 P00492 99.07 6e-157 X-RAY
 1999-12-30 ASP A:190 A:193 20.0 0.133 -138.0 175.4 20.0 0.133 0.0 MG
PPO
PRP
HOH
 8.431
2.962
5.194
8.732
 OD2
O
OD2
OD2
 MG
C2
O2B
O
ASP B:190 B:193 40.0 0.267 -98.2 159.4 40.0 0.267 0.0 MG
PPO
PRP
HOH
 9.424
2.849
2.481
4.385
 OD2
O
N
OD1
 MG
O6
O1B
O
2vfa 1 P20035,P00492 80.48 3e-122 X-RAY
 2008-06-17 ASP A:202 A:202 11.0 0.073 S -68.1 126.8 11.0 0.073 0.0 5GP
HOH
 3.239
9.744
 CA
N
 N2
O
ASP B:202 B:202 74.0 0.493 -67.6 133.9 74.0 0.493 0.0 5GP
HOH
 2.547
7.082
 O
OD2
 N2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p00492-f1 1 P00492 100.0 2e-162 ASP A:194 A:194 46.0 0.307 -128.8 164.8